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首页> 外文期刊>International Journal of Environmental Research and Public Health >Maximum Cumulative Ratio (MCR) as a Tool for Assessing the Value of Performing a Cumulative Risk Assessment
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Maximum Cumulative Ratio (MCR) as a Tool for Assessing the Value of Performing a Cumulative Risk Assessment

机译：最大累积比率（MCR）作为评估执行累积风险评估的价值的工具

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摘要

Due to the vast number of possible combinations of chemicals to which individuals are exposed and the resource-intensive nature of cumulative risk assessments, there is a need to determine when cumulative assessments are most required. This paper proposes the use of the maximum cumulative ratio (MCR) as a tool for this evaluation. MCR is the ratio of the cumulative toxicity received by an individual from exposure to multiple chemical stressors to the largest toxicity from a single chemical stressor. The MCR is a quantitative measure of the difference in an individual’s toxicity estimated using a chemical-by-chemical approach and using an additive model of toxicity. As such, it provides a conservative estimate of the degree to which individuals’ toxicities could be underestimated by not performing a cumulative risk assessment. In an example application, MCR is shown to be applicable to the evaluation of cumulative exposures involving up to 81 compounds and to provide key insights into the cumulative effects posed by exposures to multiple chemicals. In this example, MCR values suggest that individuals exposed to combinations of chemicals with the largest Hazard Indices were dominated by the contributions of one or two compounds.
机译：由于个人所接触的化学品的可能组合数量众多，并且累积风险评估的资源密集型性质，因此需要确定何时最需要进行累积评估。本文建议使用最大累积比率（MCR）作为此评估的工具。 MCR是个体从暴露于多个化学应激源中所累积的毒性与单个化学应激源所产生的最大毒性之比。 MCR是一种定量方法，用于衡量个体毒性的差异，该差异是通过逐化学方法和毒性加成模型估算得出的。因此，它提供了一种保守的估计，即通过不进行累积风险评估可以低估个人的毒性程度。在一个示例应用程序中，显示出MCR适用于评估涉及多达81种化合物的累积暴露量，并提供了对暴露于多种化学物质所产生的累积影响的关键见解。在此示例中，MCR值表明，暴露于具有最大危害指数的化学物质组合的个人受一种或两种化合物的贡献支配。

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