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首页> 外文期刊>International Journal of Environmental Research and Public Health >Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers
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Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers

机译：横断面分析肺功能测试在预测无烟者气肿中的作用

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Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. We aimed to determine the sensitivity and specificity of pulmonary function tests (PFTs) in assessing emphysema using quantitative CT scans as the reference standard. We enrolled 224 ever-smokers (current or former) over the age of 40. CT of thorax was used to quantify the low attenuation area (% emphysema), and to measure the standardized airway wall thickness. PFTs were used individually and in combination to predict their ability to discriminate radiographic emphysema. Significant emphysema (>7%) was detected in 122 (54%) subjects. Twenty six (21%) emphysema subjects had no evidence of airflow obstruction (FEV1/FVC ratio 23% emphysema showed airflow obstruction. The sensitivity and specificity of spirometry for detecting radiographic emphysema were 79% and 75%, respectively. Standardized airway wall thickness was increased in subjects with airflow obstruction, but did not correlate with emphysema severity. In this cohort of lifetime ever-smokers, PFTs alone were inadequate for diagnosing emphysema. Airway wall thickness quantified by CT morphometry was associated with airflow limitation, but not with emphysema indicating that the heterogeneous nature of lung disease in smokers may represent distinct phenotypes.
机译：肺气肿很大程度上是一种未被充分诊断的医疗状况，在没有气道阻塞的情况下，吸烟者可能会存在。我们旨在确定使用定量CT扫描作为参考标准评估肺气肿的肺功能测试（PFT）的敏感性和特异性。我们招募了224位40岁以上的吸烟者（现在或以前）。胸部CT被用来量化低衰减区域（肺气肿百分比），并测量标准化的气道壁厚度。 PFTs可以单独使用，也可以结合使用以预测其区分放射线性肺气肿的能力。在122名（54％）受试者中检测到了严重的肺气肿（> 7％）。 26名（21％）肺气肿受试者没有气流阻塞的证据（FEV1 / FVC比23％的肺气肿显示气流阻塞;肺活量测定法检测射线照相性肺气肿的敏感性和特异性分别为79％和75％。在有气道阻塞的受试者中肺气肿的增加，但与肺气肿的严重程度无关，在这群终生吸烟者中，仅PFT不足以诊断肺气肿，通过CT形态学定量的气道壁厚度与气流受限有关，但与肺气肿无关吸烟者肺部疾病的异质性可能代表不同的表型。

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