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首页> 外文期刊>International Journal of Environmental Research and Public Health >Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease
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Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease

机译：纳米粒子和胶体是神经退行性疾病的成因。

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This review explores the processes underlying the deleterious effects of the presence of insoluble or colloidal depositions within the central nervous system. These materials are chemically unreactive and can have a prolonged residence in the brain. They can be composed of mineral or proteinaceous materials of intrinsic or exogenous origin. Such nanoparticulates and colloids are associated with a range of slow-progressing neurodegenerative states. The potential common basis of toxicity of these materials is discussed. A shared feature of these disorders involves the appearance of deleterious inflammatory changes in the CNS. This may be due to extended and ineffective immune responses. Another aspect is the presence of excess levels of reactive oxygen species within the brain. In addition with their induction by inflammatory events, these may be further heightened by the presence of redox active transition metals to the large surface area afforded by nanoparticles and amphipathic micelles.
机译：这篇综述探讨了中枢神经系统中不溶或胶体沉积物的有害作用的潜在过程。这些物质在化学上没有反应性，可以在大脑中长时间停留。它们可以由内源性或外源性的矿物或蛋白质材料组成。此类纳米微粒和胶体与一系列缓慢发展的神经退行性状态有关。讨论了这些物质潜在的毒性基础。这些疾病的共同特征是中枢神经系统出现有害的炎症变化。这可能是由于免疫反应延长和无效。另一个方面是大脑中存在过量的活性氧。除了通过炎症事件引起的氧化反应外，还可以通过氧化还原活性过渡金属的存在进一步提高这些氧化还原反应的活性，从而达到纳米颗粒和两亲胶束提供的大表面积。

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