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首页> 外文期刊>International Journal of Environmental Research and Public Health >Mercury in Hair Is Inversely Related to Disease Associated Damage in Systemic Lupus Erythematosus
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Mercury in Hair Is Inversely Related to Disease Associated Damage in Systemic Lupus Erythematosus

机译：头发中的汞与系统性红斑狼疮的疾病相关损害成反比

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Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, and environmental factors are proposed to exacerbate existing symptoms. One such environmental factor is mercury. The aim of this study was to investigate the relationship between exposure to mercury (Hg) and disease activity and disease associated damage in Total Hg concentrations in hair and urine were measured in 52 SLE patients. Dental amalgams were quantified. Disease activity was assessed using three indexes including the British Isles Lupus Assessment Group Index (BILAG). Disease associated damage was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology SLICC/ACR Damage Index. Pearson’s correlation identified a significant negative correlation between hair Hg and BILAG (r = ?0.323, p = 0.029) and SLICC/ACR (r = ?0.377, p = 0.038). Multiple regression analysis identified hair Hg as a significant predictor of disease associated damage as determined by SLICC/ACR (β = ?0.366, 95% confidence interval (CI): ?1.769, ?0.155 p = 0.019). Urinary Hg was not related to disease activity or damage. Fish consumption is the primary route of MeHg exposure in humans and the inverse association of hair Hg with disease activity observed here might be explained by the anti-inflammatory effects of n-3 long chain polyunsaturated fatty acids also found in fish.
机译：系统性红斑狼疮（SLE）是一种自身免疫性炎性疾病，提出了环境因素来加剧现有症状。一种这样的环境因素是汞。这项研究的目的是调查52例SLE患者的头发和尿液中总Hg浓度是否与汞（Hg）接触与疾病活动和疾病相关损害之间的关系。牙科汞合金被量化。使用包括不列颠群岛狼疮评估组指数（BILAG）在内的三个指数评估疾病活动。使用系统性狼疮国际合作诊所/美国风湿病学院SLICC / ACR损伤指数测量与疾病相关的损伤。皮尔森相关性确定了头发Hg与BILAG（r = 0.323，p = 0.029）和SLICC / ACR（r = 0.377，p = 0.038）之间的显着负相关。多元回归分析确定头发Hg是SLICC / ACR确定的疾病相关损害的重要预测因子（β= 0.366，95％置信区间（CI）：1.769，0.155 p = 0.019）。尿汞与疾病活动或损害无关。鱼的摄入是人类接触甲基汞的主要途径，在这里观察到的头发汞与疾病活动的负相关可能是由于鱼中也存在n-3长链多不饱和脂肪酸的抗炎作用所致。

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