...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Protective Effects of Sodium Selenite against Aflatoxin B1-Induced Oxidative Stress and Apoptosis in Broiler Spleen
【24h】

Protective Effects of Sodium Selenite against Aflatoxin B1-Induced Oxidative Stress and Apoptosis in Broiler Spleen

机译：亚硒酸钠对黄曲霉毒素B1诱导的肉鸡脾脏氧化应激及细胞凋亡的保护作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to investigate the possible protective role of sodium selenite on aflatoxin B1-induced oxidative stress and apoptosis in spleen of broilers. Two hundred one-day-old male broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB1 (AFB1 group), 0.3 mg/kg AFB1 + 0.2 mg/kg Se (+Se group I), 0.3 mg/kg AFB1 + 0.4 mg/kg Se (+Se group II) and 0.3 mg/kg AFB1 + 0.6 mg/kg Se (+Se group III), respectively. According to biochemical assays, AFB1 significantly decreased the activities of glutathione peroxidase, total superoxide dismutase, glutathione reductase, catalase and the level of glutathione hormone, while it increased the level of malondialdehyde. Moreover, AFB1 increased the percentage of apoptosis cells by flow cytometry and the occurrence of apoptotic cells by TUNEL assay. Simultaneous supplementation with sodium selenite restored these parameters to be close to those in control group. In conclusion, sodium selenite exhibited protective effects on AFB1-induced splenic toxicity in broilers by inhibiting oxidative stress and excessive apoptosis.
机译：这项研究的目的是调查亚硒酸钠对黄曲霉毒素B1诱导的肉鸡脾脏氧化应激和细胞凋亡的保护作用。将200只1日龄的雄性肉鸡分为五组，以基础饮食喂养（对照组），0.3 mg / kg AFB1（AFB1组），0.3 mg / kg AFB1 + 0.2 mg / kg Se（+ Se组） I），0.3 mg / kg AFB1 + 0.4 mg / kg Se（+ Se组II）和0.3 mg / kg AFB1 + 0.6 mg / kg Se（+ Se组III）。根据生化分析，AFB1显着降低了谷胱甘肽过氧化物酶，总超氧化物歧化酶，谷胱甘肽还原酶，过氧化氢酶和谷胱甘肽激素的活性，同时增加了丙二醛的水平。此外，AFB1通过流式细胞术增加凋亡细胞的百分比，并通过TUNEL分析增加凋亡细胞的发生。同时补充亚硒酸钠可以使这些参数接近对照组。总之，亚硒酸钠通过抑制氧化应激和过度凋亡而对AFB1诱导的肉鸡脾毒性具有保护作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号