...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >An Assessment of the Interindividual Variability of Internal Dosimetry during Multi-Route Exposure to Drinking Water Contaminants
【24h】

An Assessment of the Interindividual Variability of Internal Dosimetry during Multi-Route Exposure to Drinking Water Contaminants

机译：饮用水污染物多途径暴露过程中内部剂量学的个体差异评估

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The objective of this study was to evaluate inter-individual variability in absorbed and internal doses after multi-route exposure to drinking water contaminants (DWC) in addition to the corresponding variability in equivalent volumes of ingested water, expressed as liter-equivalents (LEQ). A multi-route PBPK model described previously was used for computing the internal dose metrics in adults, neonates, children, the elderly and pregnant women following a multi-route exposure scenario to chloroform and to tri- and tetra-chloroethylene (TCE and PERC). This scenario included water ingestion as well as inhalation and dermal contact during a 30-min bathroom exposure. Monte Carlo simulations were performed and distributions of internal dose metrics were obtained. The ratio of each of the dose metrics for inhalation, dermal and multi-route exposures to the corresponding dose metrics for the ingestion of drinking water alone allowed computation of LEQ values. Mean BW-adjusted LEQ values based on absorbed doses were greater in neonates regardless of the contaminant considered (0.129–0.134 L/kg BW), but higher absolute LEQ values were obtained in average adults (3.6–4.1 L), elderly (3.7–4.2 L) and PW (4.1–5.6 L). LEQ values based on the parent compound’s AUC were much greater than based on the absorbed dose, while the opposite was true based on metabolite-based dose metrics for chloroform and TCE, but not PERC. The consideration of the 95th percentile values of BW-adjusted LEQ did not significantly change the results suggesting a generally low intra-subpopulation variability during multi-route exposure. Overall, this study pointed out the dependency of the LEQ on the dose metrics, with consideration of both the subpopulation and DWC.
机译：这项研究的目的是评估摄入饮用水污染物（DWC）的多途径暴露后，吸收剂量和内部剂量之间的个体差异，以及相应的摄入水当量体积（以升当量（LEQ）表示）之间的差异。 。先前描述的多途径PBPK模型用于计算成人，新生儿，儿童，老年人和孕妇在氯仿，三氯和四氯乙烯（TCE和PERC）的多途径暴露情况下的内部剂量指标。 。这种情况包括在浴室暴露30分钟期间摄入水，吸入和皮肤接触。进行了蒙特卡洛模拟并获得了内部剂量指标的分布。吸入，皮肤和多途径暴露的每种剂量指标与仅摄入饮用水的相应剂量指标之比允许计算LEQ值。不论考虑何种污染物，基于吸收剂量的经体重调整的平均LEQ值均较高（无论考虑的污染物为（0.129-0.134 L / kg BW），但在成年人（3.6-4.1 L），老年人（3.7- 4.2 L）和PW（4.1–5.6 L）。基于母体化合物的AUC的LEQ值远大于基于吸收剂量的LEQ值，而基于代谢物的氯仿和TCE（而非PERC）的剂量指标则相反。 BW调整的LEQ的第95个百分位数值的考虑并没有显着改变结果，表明多途径暴露期间亚群内变异性通常较低。总的来说，这项研究指出了LEQ对剂量指标的依赖性，同时考虑了亚群和DWC。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号