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首页> 外文期刊>International Journal of Environmental Research and Public Health >Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study
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Correlation between Prenatal Exposure to Polybrominated Diphenyl Ethers (PBDEs) and Infant Birth Outcomes: A Meta-Analysis and an Experimental Study

机译：产前暴露于多溴二苯醚（PBDEs）与婴儿出生结局的相关性：荟萃分析和实验研究

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Only a few epidemiological studies have focused on the correlation between prenatal exposure to polybrominated diphenyl ethers (PBDEs) and infant birth outcomes (IBO), and the results of these epidemiological studies are contradictory. The objective of this study was to assess the correlation between prenatal exposure to PBDEs (PEP) and IBO (i.e., birth weight) in an analysis of epidemiological studies and an experimental animals study. We searched databases of the medical literature (PubMed, Excerpta Medica Database, Cochrane Library, and China National Knowledge Infrastructure) for articles and pooled the results of the included epidemiological studies. In parallel, birth outcomes (i.e., birth weights of pups) were collected from female Sprague-Dawley (SD) rats exposed to decabromodiphenyl ether (DecaBDE) in the diet from five weeks of age to delivery. A significant negative relationship was found between human PBDE burden and birth weight in the analysis of seven epidemiological studies based on a random-effects model (β = ?50.598; 95% confidence interval (CI) ?95.914, ?5.282; I 2 = 11.8%; p = 0.029). In the experimental animal study, a significant decrease in birth weight in the DecaBDE-treated group was also observed (5.26 ± 0.39 vs. 5.8 ± 0.58, p = 0.0132). The results of our study contribute to increasing evidence suggesting that PEP adversely impacts IBO, especially birth weight.
机译：仅有少数流行病学研究集中在产前暴露于多溴二苯醚（PBDEs）与婴儿出生结局（IBO）之间的相关性上，这些流行病学研究的结果相互矛盾。这项研究的目的是在流行病学研究和实验动物研究中评估产前暴露于多溴二苯醚（PEP）和IBO（即出生体重）之间的相关性。我们在医学文献数据库（PubMed，Excerpta Medica数据库，Cochrane图书馆和中国国家知识基础设施）中进行搜索，并汇总了包括的流行病学研究结果。同时，从五周龄到分娩的饮食中，从暴露于十溴二苯醚（DecaBDE）的雌性Sprague-Dawley（SD）大鼠中收集出生结局（即幼崽的出生体重）。在一项基于随机效应模型的7项流行病学研究的分析中，发现人的PBDE负担与出生体重之间存在显着的负相关关系（β= 50.598; 95％置信区间（CI）95.914，5.282; I 2 = 11.8 ％; p = 0.029）。在实验动物研究中，在使用十溴二苯醚的组中出生体重也显着下降（5.26±0.39对5.8±0.58，p = 0.0132）。我们的研究结果有助于增加证据，表明PEP会对IBO产生不利影响，尤其是出生体重。

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