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首页> 外文期刊>International Journal of Environmental Research and Public Health >Overview of Evidence in Prevention and Aetiology of Food Allergy: A Review of Systematic Reviews
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Overview of Evidence in Prevention and Aetiology of Food Allergy: A Review of Systematic Reviews

机译：食物过敏的预防和病因学证据概述：系统评价的回顾

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The worldwide prevalence of food allergy appears to be increasing. Early life environmental factors are implicated in the aetiology of this global epidemic. The largest burden of disease is in early childhood, where research efforts aimed at prevention have been focused. Evidence synthesis from good quality systematic reviews is needed. We performed an overview of systematic reviews concerning the prevention and aetiology of food allergy, retrieving 14 systematic reviews, which covered three broad topics: formula (hydrolysed or soy) for the prevention of food allergy or food sensitization; maternal and infant diet and dietary supplements for the prevention of food allergy or food sensitization and hygiene hypothesis-related interventions. Using the AMSTAR criteria for assessment of methodological quality, we found five reviews to be of high quality, seven of medium quality and two of low quality. Overall we found no compelling evidence that any of the interventions that had been systematically reviewed were related to the risk of food allergy. Updating of existing reviews, and production of new systematic reviews, are needed in areas where evidence is emerging for interventions and environmental associations. Furthermore, additional primary studies, with greater numbers of participants and objective food allergy definitions are urgently required.
机译：全世界食物过敏的流行似乎正在增加。早年环境因素与这种全球流行病的病因有关。疾病的最大负担是在幼儿期，其中集中在旨在预防的研究工作。需要从高质量的系统评价中收集证据。我们对有关食物过敏的预防和病因学的系统评价进行了概述，检索了14篇系统评价，涵盖了三个广泛的主题：预防食物过敏或食物致敏的配方（水解或大豆）;母婴饮食和膳食补充剂，用于预防食物过敏或食物过敏以及与卫生假设相关的干预措施。使用AMSTAR标准对方法学质量进行评估，我们发现有5篇评论为高质量，其中7篇为中等质量，另外2篇为低质量。总体而言，我们没有令人信服的证据表明，经过系统审查的任何干预措施均与食物过敏风险有关。在干预和环境协会的证据不断涌现的领域中，需要更新现有审查并产生新的系统审查。此外，迫切需要更多的基础研究，包括更多的参与者和客观的食物过敏定义。

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