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Setting the Research Agenda on the Health Effects of Chemicals

机译：制定化学品对健康的影响研究议程

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In 2011, World Health Organization (WHO) scientists reported that a significant percentage of global deaths and disability-adjusted life years (DALYs) in 2004 could be attributed to chemicals. The 2011 review focused only on certain chemicals, however, and concluded that the global burden of disease was underestimated because of serious data gaps. While various chemical assessment documents have identified research needs for individual chemicals, a systematic review of such documents to identify research themes that could be applied to the multitude of chemicals for which there is little information has not been done. Even for chemicals for which there are considerable data, the information is not sufficient to make an estimate of the chemical’s contribution to the burden of disease. The WHO Environmental Health Criteria (EHC) documents and Concise International Chemical Assessment Documents (CICADs) identify research needs or data gaps in our knowledge of chemicals. We identified several common themes in these documents and in documents prepared by WHO on 10 chemicals of major public health concern. These themes include biomarkers, longitudinal epidemiological studies, mechanisms of disease, reproductive and developmental effects and exposure assessment. Specific examples of data gaps culled from more than 300 WHO documents provide researchers with specific topics for further research.
机译：2011年，世界卫生组织（WHO）的科学家报告说，2004年全球死亡和残疾调整生命年（DALYs）的很大一部分可能归因于化学物质。然而，2011年的审查仅关注某些化学物质，并得出结论，由于严重的数据缺口，全球疾病负担被低估了。尽管各种化学品评估文件已经确定了对每种化学品的研究需求，但尚未对这些文件进行系统的审查以识别可应用于几乎没有任何信息的多种化学品的研究主题。即使对于具有大量数据的化学品，该信息也不足以估计该化学品对疾病负担的贡献。世卫组织环境健康标准（EHC）文件和简明国际化学评估文件（CICAD）确定了我们对化学知识的研究需求或数据缺口。我们在这些文件和世卫组织编写的有关10种主要公共卫生关注的化学药品的文件中确定了几个共同主题。这些主题包括生物标志物，纵向流行病学研究，疾病机理，生殖和发育影响以及接触评估。从300多个WHO文献中消除的数据缺口的特定示例为研究人员提供了进一步研究的特定主题。

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