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首页> 外文期刊>International Journal of Environmental Research and Public Health >Resistance to Extended-Spectrum β-Lactamases in Salmonella from a Broiler Supply Chain
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Resistance to Extended-Spectrum β-Lactamases in Salmonella from a Broiler Supply Chain

机译:肉鸡供应链中沙门氏菌对广谱β-内酰胺酶的耐药性

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The prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae varies worldwide, however, the incidence of ESBL-producing environmental Salmonella isolates is increasing. Salmonella is still one of the most important pathogens that occur in the poultry supply chain. Therefore, this study analyzed the susceptibility of Salmonella isolates collected from a poultry supply chain to β-lactam antibiotics, and examined the phenotypes of the isolates based on enzyme-inducible AmpC β-lactamase analysis. All analysis of the putative positive isolates in the current study confirmed that 27.02% (77/285 analysis) of all ESBL tests realized with the isolates produced a profile of resistance consistent with β-lactamase production. All isolates of S. Minnesota serotype had ESBL phenotype. Aztreonam resistance was the least common amongst the Salmonella isolates, followed by ceftazidime. The presence of inducible chromosomal ESBL was detected in 14 different isolates of the 19 serotypes investigated. These results are very indicatives of the presence of ESBL genes in Salmonella isolates from a broiler supply chain, reaffirming the growing global problem of ESBL resistance.
机译:全世界生产广谱β-内酰胺酶(ESBL)肠杆菌科的患病率各不相同,但是,生产ESBL的环境沙门氏菌分离株的发病率正在增加。沙门氏菌仍然是家禽供应链中最重要的病原体之一。因此,本研究分析了从家禽供应链中收集的沙门氏菌对β-内酰胺类抗生素的敏感性,并基于酶诱导的AmpCβ-内酰胺酶分析检查了分离物的表型。当前研究中所有对阳性阳性分离物的分析均证实,用分离物实现的所有ESBL测试中有27.02%(分析率为77/285)产生了与β-内酰胺酶生产相符的抗药性。明尼苏达州血清型的所有分离株均具有ESBL表型。在沙门氏菌中,对氨曲南的耐药性最不常见,其次是头孢他啶。在研究的19种血清型的14种不同分离株中检测到可诱导染色体ESBL的存在。这些结果非常表明在来自肉鸡供应链的沙门氏菌分离物中存在ESBL基因,这再次证明了ESBL抗药性的全球性问题日益严重。

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