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首页> 外文期刊>International Journal of Environmental Research and Public Health >A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data
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A Toxicological Framework for the Prioritization of Children’s Safe Product Act Data

机译：优先考虑儿童安全产品法数据的毒理学框架

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In response to concerns over hazardous chemicals in children’s products, Washington State passed the Children’s Safe Product Act (CSPA). CSPA requires manufacturers to report the concentration of 66 chemicals in children’s products. We describe a framework for the toxicological prioritization of the ten chemical groups most frequently reported under CSPA. The framework scores lifestage, exposure duration, primary, secondary and tertiary exposure routes, toxicokinetics and chemical properties to calculate an exposure score. Four toxicological endpoints were assessed based on curated national and international databases: reproductive and developmental toxicity, endocrine disruption, neurotoxicity and carcinogenicity. A total priority index was calculated from the product of the toxicity and exposure scores. The three highest priority chemicals were formaldehyde, dibutyl phthalate and styrene. Elements of the framework were compared to existing prioritization tools, such as the United States Environmental Protection Agency’s (EPA) ExpoCast and Toxicological Prioritization Index (ToxPi). The CSPA framework allowed us to examine toxicity and exposure pathways in a lifestage-specific manner, providing a relatively high throughput approach to prioritizing hazardous chemicals found in children’s products.
机译：为了回应对儿童产品中有害化学物质的担忧，华盛顿州通过了《儿童安全产品法》（CSPA）。 CSPA要求制造商报告儿童产品中66种化学物质的浓度。我们描述了在CSPA下最常报告的十个化学类别的毒理学优先排序的框架。该框架对生命周期，暴露时间，主要，次要和三次暴露途径，毒物动力学和化学性质进行评分，以计算暴露得分。根据选定的国家和国际数据库评估了四个毒理学终点：生殖和发育毒性，内分泌干扰，神经毒性和致癌性。根据毒性和暴露分数的乘积计算总优先级指数。三种最优先的化学品是甲醛，邻苯二甲酸二丁酯和苯乙烯。该框架的元素与现有的优先级排序工具进行了比较，例如美国环境保护局（EPA）的ExpoCast和毒理学优先级指数（ToxPi）。 CSPA框架使我们能够以生命周期特定的方式检查毒性和暴露途径，从而提供了一种相对较高的通量方法来对儿童产品中的有害化学物质进行优先排序。

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