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首页> 外文期刊>International Journal of Environmental Research and Public Health >Diurnal Changes in Distribution Characteristics of Salivary Cortisol and Immunoglobulin A Concentrations
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Diurnal Changes in Distribution Characteristics of Salivary Cortisol and Immunoglobulin A Concentrations

机译：唾液皮质醇和免疫球蛋白A浓度分布特征的日变化。

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Salivary cortisol and secretory immunoglobulin A (S-IgA) are important biomarkers for environmental and public health research. The present study investigated the diurnal variations of these salivary biomarkers, with a focus on the change of distribution characteristics (i.e., skewness and kurtosis) of the concentrations. The participants in this study were 113 healthy young males. Salivary samples were collected in the morning (6:30–7:30 a.m.) and afternoon (1:00–4:00 p.m.). The skewness and kurtosis of salivary cortisol concentrations in afternoon samples (skewness = 1.06, kurtosis = 4.78) were significantly higher than those in morning samples (skewness = 0.49, kurtosis = 2.80). The differences in skewness and kurtosis of S-IgA concentrations were non-significant; however, the standard deviation and interquartile ranges for afternoon S-IgA concentrations were significantly smaller than those for morning S-IgA concentrations. Logarithmic transformation improved the distribution of afternoon cortisol values, making it an almost normal distribution, but the transformation showed no improvement in the distribution of morning cortisol or S-IgA values. The present study explored diurnal changes in the distribution characteristics of salivary cortisol and S-IgA. Consideration of a possible diurnal change in the distribution characteristics is needed when we compare the difference in these salivary biomarkers between different times of day.
机译：唾液皮质醇和分泌性免疫球蛋白A（S-IgA）是环境和公共卫生研究的重要生物标志物。本研究调查了这些唾液生物标志物的昼夜变化，重点是浓度分布特征（即偏度和峰度）的变化。这项研究的参与者是113名健康的年轻男性。在早上（上午6：30–7：30）和下午（下午1：00–4：00）收集唾液样本。下午样本中唾液皮质醇浓度的偏度和峰度（偏度= 1.06，峰度= 4.78）显着高于早晨样本（偏度= 0.49，峰度= 2.80）。 S-IgA浓度的偏度和峰度差异不显着;然而，下午S-IgA浓度的标准偏差和四分位数范围显着小于早上S-IgA浓度的标准偏差和四分位数范围。对数转换改善了下午皮质醇值的分布，使其几乎呈正态分布，但该转换显示早晨皮质醇或S-IgA值的分布没有改善。本研究探讨了唾液皮质醇和S-IgA分布特征的日变化。当我们比较一天中不同时间之间这些唾液生物标志物的差异时，需要考虑分布特征可能的昼夜变化。

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