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首页> 外文期刊>International Journal of Environmental Research and Public Health >Prevalence of Oral Clefts among Live Births in Gansu Province, China
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Prevalence of Oral Clefts among Live Births in Gansu Province, China

机译：甘肃省活产婴儿口裂的患病率

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Background: Oral clefts (OCs) are common human birth defects. Children with OCs in underdeveloped regions are more likely to suffer from poverty and hardship in their future lives. Here, we attempted to estimate the prevalence of OCs among live births in Gansu Province in 2008 to understand the epidemiologic pattern of the disease. Methods: A cross-sectional study was conducted from January 2008 to December 2008 in Gansu Province. The live births delivered between January and December 2008 with OCs were investigated through face-to-face questionnaire survey. Results: A total of 468 infants with OCs were identified among 347,137 live births in 2008 in Gansu Province, which yielded a prevalence of 1.35 per 1000 live births. The majority of these cases were CL (cleft lip) (prevalence = 0.85 per 1000 live births), and the prevalence of CLP (cleft lip and palate) and CP (cleft palate) was 0.34 and 0.11 per 1000 live births, respectively. We also found that the prevalence of OCs in Jiayuguan (3.39 per 1000 live births) and Dingxi (2.71 per 1000 live births) was higher than those of other cities in Gansu Province. Additionally, we failed to detect significant correlation between economic conditions of the cities and the prevalence of OCs in our study. Conclusions: The prevalence of OCs among live births in Gansu Province in 2008 was higher than the prevalence of OCs in other provinces in China. The high prevalence may reflect the need for further etiological studies to explore the potential risk factors in this region. In addition, more subtype information needs to be collected in future prevalence studies for better understanding of the epidemiologic pattern of the disease.
机译：背景：口裂（OCs）是人类常见的出生缺陷。欠发达地区的拥有儿童基金会的儿童在未来生活中更容易遭受贫困和困苦。在这里，我们试图估计2008年甘肃省活产婴儿中OC的患病率，以了解该病的流行病学模式。方法：从2008年1月至2008年12月在甘肃省进行横断面研究。通过面对面问卷调查，调查了2008年1月至12月之间通过OC进行的活产。结果：2008年，甘肃省347137例活产中共鉴定出468例OCs婴儿，每1000例活产中的患病率为1.35。这些病例中大多数为CL（唇裂）（每1000例活产患病率为0.85），CLP（唇（裂）和CP（c裂）患病率分别为每1000例活产0.34和0.11。我们还发现，嘉yu关（每千活产3.39）和定西（每千活产2.71）的超标率高于甘肃省其他城市。此外，在我们的研究中，我们未能发现城市的经济状况与OC的流行之间存在显着的相关性。结论：2008年甘肃省活产婴儿中OCs的患病率高于中国其他省份的OCs患病率。高患病率可能反映了需要进行进一步的病因学研究，以探索该地区的潜在危险因素。此外，在未来的流行研究中需要收集更多的亚型信息，以更好地了解该疾病的流行病学模式。

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