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首页> 外文期刊>International Journal of Environmental Research and Public Health >Searching for the Role of the IFNγ rs2430561 Polymorphism in Inducible Inflammation: Contribution to Metabolic Syndrome in 45 to 60-Year-Old Women
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Searching for the Role of the IFNγ rs2430561 Polymorphism in Inducible Inflammation: Contribution to Metabolic Syndrome in 45 to 60-Year-Old Women

机译：搜索的IFNγrs2430561多态性在诱导性炎症中的作用：代谢综合征在45至60岁妇女的贡献。

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摘要

Metabolic syndrome (MetS) is a cluster of conditions, increasing the risk of developing diseases that can lead to premature death. Interferon γ-inducible (the production of which is dependent on the IFNγ rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFNγ gene polymorphisms and serum levels of markers of interferon-gamma (IFNγ)-inducible inflammatory cascade. The study sample consisted of 416 women, including 118 (28.4%) with MetS. The research procedure involved interview, anthropometric measurements, and blood collection. Kynurenine levels were significantly higher in the group of women with MetS. In the group with MetS, the A/T genotype of the IFNγ gene was accompanied by higher kynurenine levels. A direct relationship between the IFNγ gene polymorphisms and the rest of the markers of IFNγ-inducible inflammatory cascade was not confirmed with regard to MetS in 45 to 60-year-old women. A disparity in the kynurenine level, as well as the relationship between the presence of the A/T genotype of the IFNγ gene and a higher level of kynurenine in the group of women with MetS, may indicate an association between inflammation, metabolic disorders and tryptophan-kynurenine inflammatory cascade.
机译：代谢综合症（MetS）是一系列疾病，增加了罹患可能导致过早死亡的疾病的风险。 γ诱导型干扰素（其产生取决于IFNγrs2430561多态性）色氨酸-犬尿氨酸炎症级联有助于了解炎症过程与MetS之间的关联性增加，这就是为什么我们寻求IFNγ基因多态性与血清TNF水平之间的关系干扰素-γ（IFNγ）诱导的炎症级联反应的标志物。研究样本包括416名妇女，其中118名（28.4％）患有MetS。研究过程涉及访谈，人体测量和血液采集。患有MetS的女性中的Kynurenine水平显着更高。在具有MetS的组中，IFNγ基因的A / T基因型伴随着较高的犬尿氨酸水平。对于45岁至60岁的女性，未证实IFN-γ基因多态性与IFN-γ可诱导的炎症级联反应的其他标记之间存在直接关系。 MetS组女性中犬尿氨酸水平的差异以及IFNγ基因A / T基因型的存在与犬尿氨酸水平的升高之间的关系可能表明炎症，代谢紊乱和色氨酸之间存在关联-犬尿氨酸炎性级联反应。

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