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首页> 外文期刊>International Journal of Environmental Research and Public Health >Primary Prevention of Lead Exposure—Blood Lead Results at Age Two Years
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Primary Prevention of Lead Exposure—Blood Lead Results at Age Two Years

机译：铅暴露的一级预防-两岁时血铅结果

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Objectives: The Philadelphia Lead Safe Homes (LSH) Study was designed to evaluate whether educational and environmental interventions in the first year of life for families of newborns increased knowledge of lead exposure prevention and were associated with less elevation of blood lead levels (BLLs) for these children, when compared to children receiving standard care. Methods: The current study performed descriptive statistics on the second-year BLL data for both groups and compared these using chi-square tests for proportions and unpaired t-tests for means. Results: A BLL result was found for 159 (50.6%) of the 314 LSH cohort children and 331 (52.7%) of the 628 control children (p = 0.1). Mean and standard deviation for age at draw was 23.8 (3.4) months versus 23.6 (3.1) months (P = 0.6). Geometric mean BLLs were 3.7 versus 3.5 μg/dL (P = 0.4). The percentages of the cohort group with a BLL of ≥20, ≥10 and ≥5 μg/dL, respectively, were 0.6%, 5% and 30%; for the controls 1.2%, 6.6%, and 25%. These percentages were not significantly different between groups. Conclusion: A comparison of geometric mean BLLs and percentages above several BLL cut points drawn at age two years in a group of urban newborns benefitting from study interventions versus a group of similar urban children did not yield statistically significant differences. Both groups had relatively lower lead levels when compared to historical cohort groups, which may reflect a continuing downward trend in BLLs in U.S. children. The interventions did result in benefits to the families such as an increase in parental knowledge about lead exposure prevention and in-home wet cleaning activity, and a decrease in lead dust levels in study homes.
机译：目标：费城铅安全房屋（LSH）研究旨在评估新生儿家庭在出生后第一年的教育和环境干预措施是否增加了预防铅暴露的知识，并且与降低铅血铅水平（BLL）的相关性与接受标准护理的儿童相比，这些儿童。方法：本研究对两组的第二年BLL数据进行了描述性统计，并使用卡方检验进行了比例比较，并使用未配对的t检验进行了均值比较。结果：314名LSH队列儿童中有159名（50.6％）的BLL结果，628名对照儿童中有331名（52.7％）（p = 0.1）。抽签年龄的平均和标准偏差为23.8（3.4）个月，而23.6（3.1）个月（P = 0.6）。几何平均BLL为3.7对3.5μg/ dL（P = 0.4）。 BLL≥20，≥10和≥5μg/ dL的同类人群百分比分别为0.6％，5％和30％;对照则为1.2％，6.6％和25％。这些百分比在两组之间没有显着差异。结论：受益于研究干预的一组城市新生儿与一组相似的城市儿童相比，在两年岁时得出的几何平均BLLs和高于几个BLL切点的百分比的比较在统计学上没有显着差异。与历史同类人群相比，这两组人群的铅水平相对较低，这可能反映出美国儿童的BLL持续下降趋势。干预确实给家庭带来了好处，例如父母对预防铅暴露和在家中进行湿式清洁活动的了解增加，以及研究房屋中的铅尘含量降低。

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