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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Delta-Aminolevulinic Acid Dehydratase Polymorphisms on Susceptibility to Lead in Han Subjects from Southwestern China
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Effects of Delta-Aminolevulinic Acid Dehydratase Polymorphisms on Susceptibility to Lead in Han Subjects from Southwestern China

机译：Delta-氨基乙酰丙酸脱水酶多态性对西南地区汉族人群铅敏感性的影响

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This study is to determine the distribution of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism among Han subjects of the Chinese population and to study whether the polymorphism in the ALAD gene modifies the toxicity of lead in lead-exposed workers. For this purpose we conducted a cross-sectional study on 156 Chinese workers who were exposed to lead in lead-acid battery and electric-flex manufacturing plants. The authors found that the allele frequencies of ALAD1 and ALAD2 were 0.9679 and 0.0321, respectively. Workers with the ALAD 1-1 genotype were associated with higher blood lead levels than those with the ALAD 1-2 genotype. Blood and urine lead levels were much higher in storage battery workers than in cable workers. The self-conscious symptom survey showed that the incidences of debilitation, amnesia and dreaminess were much higher in those had more than five years of tenure or contact with lead on the job within the ALAD 1-1 genotype subgroup. Laboratory examinations showed that serum iron and zinc levels in workers’ with the ALAD 1-2 genotype were higher than those with the ALAD 1-1 genotype, especially in storage-battery workers. Correlation analysis indicated that the blood lead level negatively correlated with serum calcium, iron and zinc level. The data of this study suggest that the ALAD gene polymorphism and serum ion levels may modify the kinetics of lead in blood. Therefore, the authors recommend that an adequate intake of dietary calcium, iron, and zinc or the calcium, iron, and zinc supplementation should be prescribed to Chinese lead exposed workers.
机译：本研究旨在确定中国人群汉族人群中δ-氨基乙酰丙酸脱水酶（ALAD）多态性的分布，并研究ALAD基因中的多态性是否会改变铅工人中铅的毒性。为此，我们对156名在铅酸电池和电子挠性制造工厂接触铅的中国工人进行了横断面研究。作者发现，ALAD1和ALAD2的等位基因频率分别为0.9679和0.0321。具有ALAD 1-1基因型的工人的血铅水平高于具有ALAD 1-2基因型的工人。蓄电池工人的血液和尿铅水平比电缆工人的高得多。自觉症状调查显示，在ALAD 1-1基因型亚组中，任职超过五年或与铅接触超过5年的人，出现虚弱，健忘和梦想的发生率要高得多。实验室检查显示，具有ALAD 1-2基因型的工人的血清铁和锌水平高于具有ALAD 1-1基因型的工人的血清铁和锌水平，尤其是蓄电池工人。相关分析表明，血铅水平与血清​​钙，铁和锌水平呈负相关。这项研究的数据表明，ALAD基因多态性和血清离子水平可能会改变血液中铅的动力学。因此，作者建议应给中国的铅接触工人规定足够的饮食钙，铁和锌的摄入量或钙，铁和锌的补充。

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