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首页> 外文期刊>International Journal of Environmental Research and Public Health >Determinants of Exposure to Fragranced Product Chemical Mixtures in a Sample of Twins
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Determinants of Exposure to Fragranced Product Chemical Mixtures in a Sample of Twins

机译：双胞胎样品中芳香产品化学混合物暴露的决定因素

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Fragranced product chemical mixtures may be relevant for environmental health, but little is known about exposure. We analyzed results from an olfactory challenge with the synthetic musk fragrance 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopento-γ-2-benzopyran (HHCB), and a questionnaire about attitudes toward chemical safety and use of fragranced products, in a sample of 140 white and 17 black twin pairs attending a festival in Ohio. Data for each product were analyzed using robust ordered logistic regressions with random intercepts for “twin pair” and “sharing address with twin”, and fixed effects for sex, age, education, and “ever being bothered by fragrances”. Due to the small number of black participants, models were restricted to white participants except when examining racial differences. Overall patterns of association were summarized across product-types through random-effects meta-analysis. Principal components analysis was used to summarize clustering of product use. The dominant axis of variability in fragranced product use was “more vs. less”, followed by a distinction between household cleaning products and personal care products. Overall, males used fragranced products less frequently than females (adjusted proportionate odds ratio 0.55, 95% confidence interval 0.33, 0.93). This disparity was driven by personal care products (0.42, 95% CI: 0.19, 0.96), rather than household cleaning products (0.79, 95% CI: 0.49, 1.25) and was particularly evident for body lotion (0.12, 95% CI: 0.05, 0.27). Overall usage differed by age (0.64, 95% CI: 0.43, 0.95) but only hand soap and shampoo products differed significantly. “Ever being bothered by fragrance” had no overall association (0.92, 95% CI: 0.65, 1.30) but was associated with laundry detergent use (0.46, 95% CI: 0.23, 0.93). Similarly, black vs. white differences on average were not significant (1.34, 95% CI: 0.55, 3.28) but there were apparent differences in use of shampoo (0.01, 95% CI: 0.00, 0.69), body lotion (4.67, 95% CI: 1.18, 18.47), and perfume (6.22, 95% CI:1.08, 35.89). There was no overall association with thinking about product risks (0.90, 95% CI: 0.79, 1.02), nor with inability to smell HHCB (0.84, 95% CI: 0.63, 1.12). Exposure to fragranced products may differ demographically. The relevance for health disparities should be studied.
机译：香料产品的化学混合物可能与环境健康有关，但对暴露的了解很少。我们分析了合成麝香1,3,4,6,7,8-六氢-4,6,6,7,8,8-六甲基-环戊基-γ-2-苯并吡喃（HHCB）嗅觉刺激的结果，以及一份关于化学安全性和使用香精产品的态度的调查表，来自参加俄亥俄州音乐节的140对白色和17对黑色双胞胎样本。使用稳健的有序逻辑回归分析对每种产品的数据进行分析，对“双胞胎”和“与双胞胎共享地址”进行随机截距，并对性别，年龄，文化程度和“被香水打扰”的固定效应进行分析。由于黑人参与者的数量很少，因此模型只限于白人参与者，除非检查种族差异。通过随机效应荟萃分析，总结了整个产品类型之间的关联的总体模式。主成分分析用于总结产品使用的聚类。香精产品使用中的可变性主导轴是“多对少”，其次是区分家用清洁产品和个人护理产品。总体而言，男性使用香料产品的频率低于女性（调整后的比值比为0.55，95％置信区间为0.33，0.93）。这种差异是由个人护理产品（0.42，95％CI：0.19，0.96）驱动的，而不是由家用清洁产品（0.79，95％CI：0.49，1.25）驱动的，尤其是对于身体乳液（0.12，95％CI： 0.05，0.27）。总体使用情况因年龄而异（0.64，95％CI：0.43，0.95），但只有洗手液和洗发水产品有显着差异。 “被香水打扰”没有整体关联（0.92，95％CI：0.65，1.30），但与洗衣粉的使用相关（0.46，95％CI：0.23，0.93）。同样，黑人与白人之间的平均差异也不显着（1.34，95％CI：0.55，3.28），但洗发水的使用方面存在明显差异（0.01，95％CI：0.00，0.69），润肤露（4.67，95） ％CI：1.18、18.47）和香料（6.22，95％CI：1.08，35.89）。与对产品风险的思考（0.90，95％CI：0.79，1.02）没有全面的关联，也与无法闻到HHCB（0.84，95％CI：0.63，1.12）没有任何关联。暴露于加香产品的人群可能会有所不同。应研究与健康差异的相关性。

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