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首页> 外文期刊>International Journal of Environmental Research and Public Health >Association of PNC, BC, and PM2.5 Measured at a Central Monitoring Site with Blood Pressure in a Predominantly Near Highway Population
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Association of PNC, BC, and PM2.5 Measured at a Central Monitoring Site with Blood Pressure in a Predominantly Near Highway Population

机译：在中央监测点测得的PNC，BC和PM2.5与主要在高速公路附近人群中的血压的关联

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Elevated blood pressure is an indicator of cardiovascular stress and increased risk of cardiovascular-related morbidity and mortality. There is emerging evidence suggesting air pollutants, including particulate matter (PM), could promote hypertension, thereby increasing cardiovascular disease risk. Repeated measurement analyses were conducted to examine the associations of three types of PM with systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) in 220 participants, (mean age = 58.5 years) from the Community Assessment of Freeway Exposure and Health study (CAFEH), most of whom live near a major highway. Ambient levels of air pollutants including particle number concentration (PNC; a measure of ultrafine particle (UFP) concentration), fine PM (PM2.5, Particle diameter <2.5 μm), and black carbon (BC) were measured at a central site <7 km from the study areas. Central sites are good at capturing short-term temporal trends in pollution associated with meteorological changes over regional areas. Linear mixed-effect models that accounted for repeated measures within one person were used to examine the associations between blood pressure variables and daily average of ambient PNC, PM2.5, or BC, controlling for demographic characteristics and major confounders including temperature. Our PNC model predicted that a higher PNC of 10,000 particles/cm3 was associated with higher DBP of 2.40 mmHg (p = 0.03), independent of other factors in the model. There were no significant associations for PM2.5 or BC. Post hoc subgroup analyses by obesity status showed that positive associations of DBP with PNC were more pronounced among obese individuals than non-obese individuals. These results suggested that PNC levels are associated with increased blood pressure, which may contribute to cardiovascular disease risk. More research is needed to assess the relationship between PNC and blood pressure and to address possible residual confounding.
机译：血压升高是心血管压力和心血管相关发病率和死亡率增加的指标。越来越多的证据表明，包括颗粒物（PM）在内的空气污染物会促进高血压，从而增加心血管疾病的风险。进行了重复测量分析，以检查来自社区评估的220名参与者（平均年龄= 58.5岁）中三种类型的PM与收缩压（SBP），舒张压（DBP）和脉压（PP）的关联。高速公路暴露与健康研究（CAFEH）的研究，其中大多数居住在主要高速公路附近。在中心位置测量的空气污染物的环境水平包括颗粒数浓度（PNC;超细颗粒物（UFP）浓度的度量​​），细颗粒物PM（PM2.5，粒径<2.5μm）和黑碳（BC）。距学习区7公里。中心站点擅长捕捉与区域范围内的气象变化相关的污染的短期时间趋势。使用线性混合效应模型（考虑一个人的重复测量）来检查血压变量与周围PNC，PM2.5或BC日平均水平之间的关联，以控制人口统计学特征和主要混杂因素，包括温度。我们的PNC模型预测，与模型中的其他因素无关，较高的PNC为10,000颗粒/ cm3与较高的DBP为2.40 mmHg（p = 0.03）相关。没有PM2.5或BC的显着关联。肥胖状况的事后亚组分析表明，肥胖个体中DBP与PNC的正相关比非肥胖个体更为明显。这些结果表明，PNC水平与血压升高有关，这可能会增加心血管疾病的风险。需要更多的研究来评估PNC与血压之间的关系并解决可能的残留混杂。

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