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首页> 外文期刊>International Journal of Environmental Research and Public Health >Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities
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Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities

机译：合理修饰的雌激素受体蛋白作为检测EDC污染物的生物识别元件：策略和机会

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摘要

The estrogen receptor protein (ER) can bind a vast number of organic pollutants widely spread in the environment and collectively known as Endocrine Disrupting Chemicals, EDCs. Its broad selectivity makes it an ideal bio-recognition element for the detection of EDCs. Here we describe the strategy and rationale for the design of ER based biosensors and assays that generate a signal in the presence of EDCs. The opportunity to use either natural or rationally modified ER molecules is discussed. The latter approach was successfully applied in the EU-FP7 project RADAR, with the aim to develop a novel biosensor for the detection of organic pollutants both in the environment and in commercial water products.
机译：雌激素受体蛋白（ER）可以结合广泛分布在环境中的多种有机污染物，这些物质统称为内分泌干扰化学物质（EDC）。其广泛的选择性使其成为检测EDC的理想生物识别元件。在这里，我们描述了基于ER的生物传感器和在EDCs的存在下产生信号的检测法设计的策略和原理。讨论了使用天然或合理修饰的ER分子的机会。后一种方法已成功应用于EU-FP7项目RADAR，目的是开发一种新型生物传感器，用于检测环境和商业水产品中的有机污染物。

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