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首页> 外文期刊>International Journal of Exercise Science >The Influence of Short-term Quercetin Supplementation on Peak Oxygen Uptake During Simulated Altitude Exposure in Trained Cyclists
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The Influence of Short-term Quercetin Supplementation on Peak Oxygen Uptake During Simulated Altitude Exposure in Trained Cyclists

机译：在训练有素的骑自行车者中，短期补充槲皮素对模拟氧气暴露过程中峰值氧吸收的影响

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Endurance performance and peak oxygen uptake (VO2peak) decline as altitude increases. Some data exist suggesting that quercetin supplementation improves aerobic capacity in trained and untrained individuals at sea-level (normobaric normoxic conditions). Few studies have examined the effects of quercetin on endurance performance during simulated altitude exposure (normobaric hypoxic conditions). The purpose of this study was to determine the effects of consuming 1000 mg·day-1 of quercetin for two weeks on cycling VO2peak in healthy trained male cyclists performing under normobaric normoxic and hypoxic conditions (NP and HP, respectively). Fourteen age-matched healthy male subjects were randomized to either a placebo or quercetin group. Baseline and post supplementation VO2peak values were quantified during incremental cycling under normobaric normoxic (FIO2 = 20.9%) and normobaric hypoxic (FIO2 = 13.6 + 0.2%) conditions. Subjects consumed capsules twice daily with either 500 mg quercetin or placebo (Tang) for two weeks and were re-assessed. Test order was randomized and assessments were separated by 48-72 hours. At baseline, there were no significant differences between groups for VO2peak normobaric normoxic trials (NPbaseline Placebo vs. NPbaseline Quercetin = 58.7+8.8 and 61.5+7.9 ml . kg-1 . min-1, respectively, p = 0.541) and normobaric hypoxic trials (HPbaseline Placebo vs. HPbaseline Quercetin = 48.5+8.3 and 50.8+4.8 ml . kg-1 . min-1, respectively, p = 0.534). No significant differences were found after treatment (Placebo: NPbaseline vs. NPpost = 58.7+ 8.8 and 56.7+7.4 ml . kg-1 . min-1, respectively, p = 0.10; HPbaseline vs .HPpost = 48.5+8.3 and 47.1+8.3, respectively, p = 0.50; Quercetin: NPbaseline vs. NPpost = 61.5+7.9 and 62.4+7.3 ml . kg-1 . min-1, respectively, p = 0.558; HPbaseline vs. HPpost = 50.8+4.8 and 51.2+3.8 ml . kg-1 . min-1, respectively, p= 0.656. These data suggest that short-term quercetin supplementation at 1000 mg . day-1 does not affect VO2peak elicited via incremental maximal cycle testing under normobaric normoxic and hypoxic conditions in trained male cyclists. Furthermore, quercetin supplementation did not attenuate the decline in VO2peak that was evident in the normobaric hypoxic condition.
机译：耐力性能和峰值摄氧量（VO2peak）随着海拔的升高而下降。存在一些数据表明槲皮素补充剂可在海平面（常压常氧条件下）补充训练有素和未经训练的个体的有氧运动能力。很少有研究检查槲皮素对模拟海拔暴露（常压低氧条件）下耐力表现的影响。这项研究的目的是确定在正常氧和低氧条件下（分别为NP和HP）进行健康训练的男性骑自行车者中，两周服用1000 mg·day-1槲皮素对自行车VO2peak的影响。十四名年龄匹配的健康男性受试者被随机分为安慰剂或槲皮素组。在常压常氧（FIO2 = 20.9％）和常压低氧（FIO2 = 13.6 + 0.2％）条件下的增量循环过程中，对基线和补充VO2peak值进行定量。受试者每天两次服用500毫克槲皮素或安慰剂（Tang）的胶囊，持续两周，然后进行重新评估。测试顺序随机分配，评估间隔48-72小时。在基线时，VO2peak常压常氧试验（NPbaseline安慰剂与NPbaseline槲皮素分别为58.7 + 8.8和61.5 + 7.9 ml。kg-1。min-1，p = 0.541）和常压低氧试验的组之间无显着差异。 （HP基线安慰剂与HP基线槲皮素分别为48.5 + 8.3和50.8 + 4.8ml.kg-1.min-1，p ＝ 0.534）。治疗后无明显差异（安慰剂：NPbaseline vs. NPpost = 58.7+ 8.8和56.7 + 7.4 ml。kg-1 .min-1，p = 0.10; HPbaseline vs.HPpost = 48.5 + 8.3和47.1 + 8.3分别为p = 0.50;槲皮素：NP基线vs. NPpost = 61.5 + 7.9和62.4 + 7.3 ml.kg-1.min-1，p = 0.558; HP基线vs.HPpost = 50.8 + 4.8和51.2 + 3.8 ml 。kg-1。min-1分别为p = 0.656。这些数据表明，在经过训练的男性常压常氧和低氧条件下，短期增量补充槲皮素不会影响通过增量最大周期试验诱发的VO2peak（VO2peak）。此外，补充槲皮素并不能减弱常压低氧状态下VO2peak的下降。

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