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首页> 外文期刊>International Journal of General Medicine >Prevalence and association of vitamin D deficiency and mortality in patients with severe sepsis
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Prevalence and association of vitamin D deficiency and mortality in patients with severe sepsis

机译：严重败血症患者中维生素D缺乏症和死亡率的患病率和关联

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Background: Vitamin D is a steroid prohormone that regulates body calcium and phosphate metabolism. Recent studies have shown an association between low vitamin D status and high mortality in patients admitted to intensive care units. To date, there are limited data available specifically about severely septic patients in medical units. Objectives: To determine the prevalence of vitamin D deficiency in severely septic patients and its clinical outcomes, including mortality rate. Methods: A prospective observational study was conducted to investigate the prevalence of vitamin D deficiency and its association with 30-day mortality in patients with severe sepsis. Patients admitted to medical wards at our hospital between November 2014 and March 2015 were included in the study. A 25-hydroxyvitamin D level <20 ng/mL was defined as vitamin D deficiency, and <12 ng/mL as severe deficiency. For an association analysis, the patients were grouped into deficient versus not deficient and severely deficient versus not severely deficient. Results: One hundred and ten eligible patients were enrolled. A total of 83 patients (75%) had vitamin D deficiency and 42 (38%) had severe deficiency. Despite an insignificant higher 30-day hospital mortality rate in vitamin D deficient versus non-deficient groups (16% vs 4%, p =0.18), the differences were significant between the severely deficient versus non-severe groups (23% vs 4%, p =0.02). The odds ratio of the 30-day mortality rate was 4.83 (95% confidence interval [CI], 0.60–38.77, p =0.14) for vitamin D deficiency and 7.69 (95% CI, 2.00–29.55, p =0.003) for severe deficiency. Conclusion: The prevalence of vitamin D deficiency was very high in three-quarters of patients with severe sepsis. A significant higher mortality rate was observed, particularly in patients with severe vitamin D deficiency.
机译：背景：维生素D是一种类固醇激素，可调节体内钙和磷酸盐的代谢。最近的研究表明，重症监护病房的患者体内低维生素D状态与高死亡率之间存在关联。迄今为止，关于医疗机构中严重脓毒症患者的可用数据有限。目的：确定严重脓毒症患者维生素D缺乏症的患病率及其临床结果，包括死亡率。方法：进行了一项前瞻性观察性研究，以调查严重败血症患者中维生素D缺乏症的患病率及其与30天死亡率的关系。研究纳入了2014年11月至2015年3月在我们医院就诊的病房的患者。 <20 ng / mL的25-羟基维生素D水平定义为维生素D缺乏症，<12 ng / mL的水平定义为严重缺乏症。为了进行关联分析，将患者分为缺陷与非缺陷，严重与非严重。结果：入选了110名合格患者。共有83名患者（75％）患有维生素D缺乏症，其中42名患者（38％）患有维生素D缺乏症。尽管维生素D缺乏组与非维生素D缺乏组的30天住院死亡率无显着差异（16％vs 4％，p = 0.18），但严重缺乏与非严重组之间差异显着（23％vs 4％） ，p ＝ 0.02）。维生素D缺乏症的30天死亡率的比值比为4.83（95％置信区间[CI]，0.60-38.77，p = 0.14），重度维生素D缺乏症为7.69（95％CI，2.00-29.55，p = 0.003）。不足。结论：严重脓毒症患者中四分之三的维生素D缺乏症患病率很高。观察到较高的死亡率，特别是严重维生素D缺乏的患者。

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