• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study
【24h】

Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

机译：CRP和TNF-α基因变异与墨西哥人群心血管心脏病之间的关联：病例对照研究方案

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The C-reactive protein ( CRP ) and the tumor necrosis factor-alpha ( TNF-α ) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-α genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.
机译：背景：C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）被认为是炎症的标志物，并已显示出可预测发生心血管事件的风险。但是，很少有研究对CRP和TNF-α基因的SNP（单核苷酸多态性）进行全面检查。因此，我们将进行一项方案研究，以评估CRP和TNF-α基因在墨西哥个体中的作用。方法/设计：我们将进行病例对照研究，以探讨CRP和TNF-α基因型分布以及rs1800947，rs1130864，rs2794521和rs1205（CRP基因的多态性）以及rs361525，rs1800629，rs1799724，患有冠状动脉疾病的墨西哥人中的rs1800630，rs1799964（TNF-α基因的）。道德与传播：将获得所有参与受试者的书面知情同意。根据STROBE标准，将详细介绍研究结果的文章提交至国际同行评审期刊上发表。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号