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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus–Uterus in Pubertal Female Rats
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Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus–Uterus in Pubertal Female Rats

机译：邻苯二甲酸二（2-乙基己基）酯对雌性青春期大鼠下丘脑–子宫的影响

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摘要

The pollution of endocrine disruptors and its impact on human reproductive system have attracted much attention. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely used in food packages, containers, medical supplies and children’s toys. It can cause diseases such as infertility, sexual precocity and uterine bleeding and thus arouse concerns from the society and scholars. The effect of DEHP on pubertal female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on the hypothalamus–uterus in pubertal female rats, reveal the reproductive toxicity of DEHP on pubertal female rats and its mechanism, and provide scientific evidence for the evaluation of toxicity and toxic mechanism of DEHP on reproductive system. Forty-eight pubertal female rats were randomly divided into four groups and respectively administered via oral gavage 0, 250, 500, or 1000 mg/kg/d DEHP in 0.1 mL corn oil/20 g body weight for up to four weeks. Compared with control rats, the DEHP-treated rats showed: (1) higher gonadotropin-releasing hormone (GnRH) level in the hypothalamus; (2) higher protein levels of GnRH in the hypothalamus; and (3) higher mRNA and protein levels of GnRH receptor (GnRHR) in the uterus. Our data reveal that DEHP exposure may lead to a disruption in pubertal female rats and an imbalance of hypothalamus–uterus. Meanwhile, DEHP may, through the GnRH in the hypothalamus and its receptor on the uterus, lead to diseases of the uterus. DEHP may impose a negative influence on the development and functioning of the reproductive system in pubertal female rats.
机译：内分泌干​​扰物的污染及其对人类生殖系统的影响已引起广泛关注。邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种环境内分泌干扰物，被广泛用于食品包装，容器，医疗用品和儿童玩具中。它会引起诸如不孕，性早熟和子宫出血等疾病，从而引起社会和学者的关注。 DEHP对青春期女性生殖系统的影响仍未得到很好的研究。本研究旨在探讨DEHP对青春期雌性大鼠下丘脑-子宫的影响，揭示DEHP对青春期雌性大鼠的生殖毒性及其作用机理，为评价DEHP对生殖系统的毒性和毒性机制提供科学依据。 。将48只青春期雌性大鼠随机分为四组，分别通过口管饲法分别以0.1mL玉米油/ 20g体重的0、250、500或1000 mg / kg / d DEHP给药，持续长达四个星期。与对照组相比，DEHP处理的大鼠表现出：（1）下丘脑中的促性腺激素释放激素（GnRH）水平较高; （2）下丘脑中GnRH的蛋白质水平较高; （3）子宫中GnRH受体（GnRHR）的mRNA和蛋白水平较高。我们的数据表明，DEHP暴露可能会导致青春期雌性大鼠破裂和下丘脑-子宫失衡。同时，DEHP可能通过下丘脑中的GnRH及其在子宫上的受体导致子宫疾病。 DEHP可能对青春期雌性大鼠生殖系统的发育和功能产生负面影响。

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