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首页> 外文期刊>International Journal of Environmental Research and Public Health >Insights from Epidemiology into Dichloromethane and Cancer Risk
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Insights from Epidemiology into Dichloromethane and Cancer Risk

机译：流行病学对二氯甲烷和癌症风险的见解

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Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of lung cancer in the cohort studies (standardized mortality ratios ranging from 0.46 to 1.21). These cohorts are relatively small, and variable effects (e.g., point estimates ranging from 0.5 to 2.0) were seen for the rarer forms of cancers such as brain cancer and specific hematopoietic cancers. Three large population-based case-control studies of incident non-Hodgkin lymphoma in Europe and the United States observed odds ratios between 1.5 and 2.2 with dichloromethane exposure (ever exposed or highest category of exposure), with higher risk seen in specific subsets of disease. More limited indications of associations with brain cancer, breast cancer, and liver and biliary cancer were also seen in this collection of studies. Existing cohort studies, given their size and uneven exposure information, are unlikely to resolve questions of cancer risks and dichloromethane exposure. More promising approaches are population-based case-control studies of incident disease, and the combination of data from such studies, with robust exposure assessments that include detailed occupational information and exposure assignment based on industry-wide surveys or direct exposure measurements.
机译：二氯甲烷（二氯甲烷）是一种广泛使用的氯化溶剂。我们回顾了现有的流行病学研究（5个队列研究，13个病例对照研究，包括7个造血系统癌症），重点关注特定的癌症部位。在队列研究中，几乎没有迹象表明肺癌风险增加（标准死亡率为0.46至1.21）。这些队列相对较小，并且对于诸如脑癌和特定的造血系统癌症的较罕见形式的癌症，观察到了不同的影响（例如，点估计为0.5至2.0）。在欧洲和美国进行的三项基于人群的大型病例对照研究中，非霍奇金淋巴瘤的发病率在1.5至2.2之间（与二氯甲烷接触（曾经接触过或接触程度最高的接触者）），在特定疾病亚群中患病风险更高。在这一系列研究中还发现了与脑癌，乳腺癌，肝癌和胆道癌相关的更有限的指征。鉴于现有队列研究的规模和暴露信息不均匀，因此不太可能解决癌症风险和二氯甲烷暴露的问题。更有前途的方法是基于人群的突发疾病病例对照研究，以及来自此类研究的数据与可靠的暴露评估，包括基于行业范围内调查或直接暴露测量的详细职业信息和暴露分配。

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