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首页> 外文期刊>International Journal of Environmental Research and Public Health >Differential Effects of High-Carbohydrate and High-Fat Diet Composition on Metabolic Control and Insulin Resistance in Normal Rats
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Differential Effects of High-Carbohydrate and High-Fat Diet Composition on Metabolic Control and Insulin Resistance in Normal Rats

机译：高碳水化合物和高脂肪饮食组成对正常大鼠代谢控制和胰岛素抵抗的差异作用

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摘要

The macronutrient component of diets is critical for metabolic control and insulin action. The aim of this study was to compare the effects of high fat diets (HFDs) vs. high carbohydrate diets (HCDs) on metabolic control and insulin resistance in Wistar rats. Thirty animals divided into five groups (n = 6) were fed: (1) Control diet (CD); (2) High-saturated fat diet (HSFD); (3) High-unsaturated fat diet (HUFD); (4) High-digestible starch diet, (HDSD); and (5) High-resistant starch diet (HRSD) during eight weeks. HFDs and HCDs reduced weight gain in comparison with CD, however no statistical significance was reached. Calorie intake was similar in both HFDs and CD, but rats receiving HCDs showed higher calorie consumption than other groups, (p < 0.01). HRSD showed the lowest levels of serum and hepatic lipids. The HUFD induced the lowest fasting glycemia levels and HOMA-IR values. The HDSD group exhibited the highest insulin resistance and hepatic cholesterol content. In conclusion, HUFD exhibited the most beneficial effects on glycemic control meanwhile HRSD induced the highest reduction on lipid content and did not modify insulin sensitivity. In both groups, HFDs and HCDs, the diet constituents were more important factors than caloric intake for metabolic disturbance and insulin resistance.
机译：饮食中的丰富营养成分对于代谢控制和胰岛素作用至关重要。这项研究的目的是比较高脂饮食（HFD）与高碳水化合物饮食（HCD）对Wistar大鼠的代谢控制和胰岛素抵抗的影响。分为五组（n = 6）的三十只动物被喂食：（1）对照饮食（CD）; （2）高饱和脂肪饮食（HSFD）; （3）高不饱和脂肪饮食（HUFD）; （4）高消化性淀粉饮食（HDSD）; （5）八周内的高抗性淀粉饮食（HRSD）。与CD相比，HFD和HCD减少了体重增加，但是没有统计学意义。 HFD和CD的卡路里摄入量相似，但接受HCD的大鼠的卡路里消耗量高于其他组（p <0.01）。 HRSD显示最低的血清和肝脂质水平。 HUFD诱导最低的空腹血糖水平和HOMA-IR值。 HDSD组表现出最高的胰岛素抵抗和肝胆固醇含量。总之，HUFD对血糖控制表现出最有益的作用，而HRSD引起的血脂减少最多，并且没有改变胰岛素敏感性。在两组（HFD和HCD）中，饮食成分比热量摄入更重要，这是代谢紊乱和胰岛素抵抗的重要因素。

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