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首页> 外文期刊>Journal of Korean medical science >Differential effects of high-carbohydrate and high-fat diet composition on muscle insulin resistance in rats.
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Differential effects of high-carbohydrate and high-fat diet composition on muscle insulin resistance in rats.

机译：高碳水化合物和高脂肪饮食组成对大鼠肌肉胰岛素抵抗的差异作用。

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摘要

This study was conducted to evaluate whether the composition of carbohydrate or fat diet affects insulin resistance by measuring the muscle glucose transport rate. Both high-sucrose and high-starch diet with or without high-fat decreased insulin-stimulated glucose transport, but there were no significant differences among groups. Calorie intake in both high-sucrose and high-starch diet groups was higher than in chow group. The high-fat high-sucrose diet induced decrease in insulin-stimulated glucose transport was partially improved by supplement with fish oil. Calorie intake in high-fat high-sucrose and fish oil supplemented groups was higher than in chow group. The decreased insulin-stimulated glucose transport was accompanied by the increase in visceral fat mass, plasma triglyceride and insulin levels. These changes were improved by the supplement with fish oil. These results demonstrate that the composition of fat in diet is clearly instrumental in the induction of muscle insulin resistance. However, in high carbohydrate diet, it is likely that the amount of calorie intake may be a more important factor in causing insulin resistance than the composition of carbohydrate. Thus, the compositions of carbohydrate and fat in diet differentially affect on muscle insulin resistance.
机译：这项研究旨在通过测量肌肉的葡萄糖转运速率来评估碳水化合物或脂肪饮食的组成是否会影响胰岛素抵抗。不论有无高脂饮食，高蔗糖和高淀粉饮食均可降低胰岛素刺激的葡萄糖转运，但各组之间无显着差异。高蔗糖和高淀粉饮食组的热量摄入均高于食物组。补充鱼油可部分改善高脂高蔗糖饮食诱导的胰岛素刺激的葡萄糖转运。高脂高蔗糖和鱼油补充组的卡路里摄入量高于食物组。胰岛素刺激的葡萄糖转运减少伴随着内脏脂肪量，血浆甘油三酸酯和胰岛素水平的增加。鱼油补充剂改善了这些变化。这些结果表明，饮食中的脂肪组成显然有助于诱导肌肉胰岛素抵抗。然而，在高碳水化合物饮食中，卡路里摄入量可能是引起胰岛素抵抗的重要因素，而不是碳水化合物组成。因此，饮食中碳水化合物和脂肪的组成对肌肉胰岛素抵抗的影响不同。

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