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首页> 外文期刊>International Journal of Environmental Research and Public Health >Hyperlipidemia and Statins Affect Neurological Outcome in Lumbar Spine Injury
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Hyperlipidemia and Statins Affect Neurological Outcome in Lumbar Spine Injury

机译：高脂血症和他汀类药物影响腰椎损伤的神经系统结果。

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The disabling pathophysiologic effects of lipid and neuroprotective effects of statins have recently been demonstrated for acute spinal cord injuries in animal models. This large scale population-based study aimed to investigate the effect hyperlipidemia and the use of statins in patients with lumbar spine injury. The National Health Insurance Research Database of Taiwan was used to identify patients with lumbar spine injury. A total of 2844 patients were grouped into three: no hyperlipidemia, hyperlipidemia using low-dose of statins (≤90 of the defined daily dosage (DDD)), and severe hyperlipidemia using high-dose of statins (>90 DDD). A Cox multiple regression model was used to compare the incidence rates of disability among the three groups. The results showed that patients with hyperlipidemia appeared a higher risk of permanent disability (adjusted HR = 1.38, p = 0.28). In subgroup analysis, patients with severe hyperlipidemia had a higher risk of disability (adjusted HR = 3.1, p < 0.004), whereas hyperlipidemia using low-dose statins had a similar risk of permanently disability (adjusted HR = 0.83, p = 0.661). Hyperlipidemia adversely affected the neurological outcomes of lumbar spinal injury. Statins may have the potential to reverse this higher risk of disability. However, this beneficiary effect of statins only existed in patients using a lower dose (≤90 DDD).
机译：最近已在动物模型中证明了他汀类药物的致死性病理生理作用和他汀类药物的神经保护作用。这项基于人群的大规模研究旨在调查高脂血症的影响以及他汀类药物在腰椎损伤患者中的使用。台湾国家健康保险研究数据库用于识别腰椎损伤患者。总共2844例患者分为三类：无高脂血症，使用低剂量他汀类药物（≤每日定义剂量（DDD）的90％）的高脂血症和使用高剂量他汀类药物（> 90 DDD）的严重高脂血症。使用Cox多元回归模型比较三组之间的残疾发生率。结果表明，高脂血症患者出现永久性残疾的风险更高（校正后的HR = 1.38，p = 0.28）。在亚组分析中，患有严重高脂血症的患者有更高的残疾风险（校正后的HR = 3.1，p <0.004），而使用低剂量他汀类药物的高脂血症具有类似的永久残疾风险（校正后的HR = 0.83，p = 0.661）。高脂血症会对腰椎脊髓损伤的神经系统后果产生不利影响。他汀类药物有可能扭转这种更高的残疾风险。但是，他汀类药物的这种有益作用仅存在于使用较低剂量（≤90 DDD）的患者中。

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