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首页> 外文期刊>International Journal of Environmental Research and Public Health >Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause
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Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause

机译：绝经后女性中雌二醇与促卵泡激素浓度及载脂蛋白E和瘦素基因多态性的关系分析

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Background : Menopause is the permanent cessation of menstruation due to loss of ovarian follicular activity. A review of the available literature indicates that correlations between the changes that take place in a woman’s body after menopause and different genetic variants are still being sought. Methods : The study was conducted in 252 women who had completed physiological menopause. The women were divided into groups according to the time elapsed since menopause. The total concentrations of estradiol and follicle-stimulating hormone were determined by means of electrochemiluminescence. The apolipoprotein E (APOE) and lepitn (LEP) genotypes were determined by real-time PCR and polymerase chain reaction–restriction fragment length polymorphism, respectively. Results : We observed that people with the APOE3/E3 genotype entered menopause insignificantly later compared to other genotypes. Additionally, in the group of patients with the APOE3/E3 genotypes, differences in the E2 concentration were significantly related to the time since their last menstruation. There is no association found in the literature between these polymorphisms of the LEP gene and hormones. Conclusions : To date, attempts to formulate a model describing the association between E2 and FSH concentration with the polymorphisms of various genes of menopause in women have not been successful. This relationship is difficult to study because of the number of nongenetic factors. Environmental factors can explain variation in postmenopausal changes in hormone levels.
机译：背景：更年期是由于卵巢卵泡活动能力丧失而导致的月经永久停止。对现有文献的回顾表明，绝经后女性体内发生的变化与不同的遗传变异之间仍存在相关性。方法：该研究是针对252名已完成生理绝经的女性进行的。根据绝经后的时间将妇女分为几组。雌二醇和促卵泡激素的总浓度通过电化学发光测定。载脂蛋白E（APOE）和lepitn（LEP）基因型分别通过实时PCR和聚合酶链反应-限制性片段长度多态性确定。结果：我们观察到具有APOE3 / E3基因型的人比其他基因型进入绝经的时间更短。此外，在具有APOE3 / E3基因型的患者中，E2浓度的差异与自上次月经以来的时间显着相关。 LEP基因的这些多态性与激素之间没有关联。结论：迄今为止，试图建立描述妇女E2和FSH浓度与更年期各种基因多态性之间关系的模型的尝试尚未成功。由于非遗传因素的数量，这种关系很难研究。环境因素可以解释绝经后激素水平的变化。

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