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首页> 外文期刊>International Journal of Environmental Research and Public Health >Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure
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Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure

机译：在反复植入失败的女性中，甲状腺自身免疫与细胞毒性T细胞减少有关。

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摘要

Thyroid autoimmunity (TAI), which is defined as the presence of autoantibodies against thyroid peroxidase (TPO) and/or thyroglobulin (TG), is related to repeated implantation failure (RIF). It is reported that TAI was involved in reproductive failure not only through leading thyroid function abnormality, but it can also be accompanied with immune imbalance. Therefore, this study was designed to investigate the association of thyroid function, immune status and TAI in women with RIF. Blood samples were drawn from 72 women with RIF to evaluate the prevalence of TAI, the thyroid function, the absolute numbers and percentages of lymphocytes. The prevalence of thyroid function abnormality in RIF women with TAI was not significantly different from that in RIF women without TAI (χ2 = 0.484, p 0.05). The absolute number and percentage of T cells, T helper (Th) cells, B cells and natural killer (NK) cells were not significantly different in RIF women with TAI compared to those without TAI (all p 0.05). The percentage of T cytotoxicity (Tc) cells was significantly decreased in RIF women with TAI compared to those without TAI (p 0.05). Meanwhile, Th/Tc ratio was significantly increased (p 0.05). These results indicated that the decreased Tc percentage and increased Th/Tc ratio may be another influential factor of adverse pregnancy outcomes in RIF women with TAI.
机译：甲状腺自身免疫（TAI）定义为存在针对甲状腺过氧化物酶（TPO）和/或甲状腺球蛋白（TG）的自身抗体，与反复植入失败（RIF）有关。据报道，TAI不仅通过导致甲状腺功能异常而参与生殖衰竭，而且还可能伴有免疫失衡。因此，本研究旨在调查RIF妇女的甲状腺功能，免疫状态和TAI的相关性。从72名RIF妇女中抽取血液样本，以评估TAI的患病率，甲状腺功能，淋巴细胞的绝对数量和百分比。有TAI的RIF妇女与没有TAI的RIF妇女的甲状腺功能异常患病率无显着差异（χ 2 = 0.484，p> 0.05）。与没有TAI的RIF妇女相比，有TAI的RIF妇女的T细胞，T辅助（Th），B细胞和自然杀伤（NK）细胞的绝对数量和百分比没有显着差异（所有p> 0.05）。与没有TAI的女性相比，有TAI的RIF女性的T细胞毒性（Tc）细胞百分比显着降低（p <0.05）。同时，Th / Tc比显着增加（p <0.05）。这些结果表明，降低的Tc百分比和增加的Th / Tc比率可能是TAI的RIF妇女不良妊娠结局的另一个影响因素。

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