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首页> 外文期刊>Autoimmunity reviews >Humoral and cellular autoimmunity in women with recurrent pregnancy losses and repeated implantation failures: A possible role of vitamin D
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Humoral and cellular autoimmunity in women with recurrent pregnancy losses and repeated implantation failures: A possible role of vitamin D

机译：反复流产和反复植入失败的女性的体液和细胞自身免疫：维生素D的可能作用

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Women with recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) have auto- and cellular immune abnormalities. Approximately, 20% of women with RPL have autoimmune abnormalities, particularly antiphospholipid antibodies (APA). In addition, these women have a higher prevalence of antinuclear antibody, anti-thyroperoxidase and anti-thyroglobulin antibodies, and other non-organ-specific autoantibodies. In women with RPL, the presence of autoimmunity is often associated with cellular immune abnormalities, such as increased NK cell levels and Th1/Th2 cell ratios. Vitamin D (VD) plays a major role in regulation of auto- and cellular immune abnormalities. VD deficiency is prevalent in women with RPL, and women with VD deficiency have increased auto- and cellular immune abnormalities as compared with women with normal VD levels. VD has immune regulatory effects on various immune effectors including T, B and NK cells. Potential therapeutic application of VD for RPL and RIF with auto- and cellular immune abnormalities should be explored. (C) 2016 Elsevier B.V. All rights reserved.
机译：反复流产（RPL）和反复植入失败（RIF）的女性具有自身和细胞免疫异常。大约有20％的RPL妇女患有自身免疫异常，特别是抗磷脂抗体（APA）。此外，这些女性的抗核抗体，抗甲状腺素过氧化物酶和抗甲状腺球蛋白抗体以及其他非器官特异性自身抗体的患病率更高。在患有RPL的女性中，自身免疫的存在通常与细胞免疫异常有关，例如NK细胞水平升高和Th1 / Th2细胞比率增加。维生素D（VD）在调节自身和细胞免疫异常中起主要作用。 VD缺乏症在RPL女性中普遍存在，与VD水平正常的女性相比，VD缺乏女性的自身和细胞免疫异常增加。 VD对包括T，B和NK细胞在内的各种免疫效应物具有免疫调节作用。应探讨VD在RPL和RIF以及自身和细胞免疫异常中的潜在治疗应用。 （C）2016 Elsevier B.V.保留所有权利。

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