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首页> 外文期刊>International Journal of Environmental Research and Public Health >Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine
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Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine

机译：与唾液可替宁相比，头发尼古丁作为长期吸烟的生物标志物的效用和临界值

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While hair samples are easier to collect and less expensive to store and transport than biological fluids, and hair nicotine characterizes tobacco exposure over a longer time period than blood or urine cotinine, information on its utility, compared with salivary cotinine, is still limited. We conducted a cross-sectional study with 289 participants (107 active smokers, 105 passive smokers with self-reported secondhand smoke (SHS) exposure, and 77 non-smokers with no SHS exposure) in Baltimore (Maryland, USA). A subset of the study participants (n = 52) were followed longitudinally over a two-month interval.? Median baseline hair nicotine concentrations for active, passive and non-smokers were 16.2, 0.36, and 0.23 ng/mg, respectively, while those for salivary cotinine were 181.0, 0.27, and 0.27 ng/mL, respectively. Hair nicotine concentrations for 10% of passive or non-smokers were higher than the 25th percentile value for active smokers while all corresponding salivary cotinine concentrations for them were lower than the value for active smokers. This study showed that hair nicotine concentration values could be used to distinguish active or heavy passive adult smokers from non-SHS exposed non-smokers. Our results indicate that hair nicotine is a useful biomarker for the assessment of long-term exposure to tobacco smoke.
机译：尽管与生物体液相比，头发样本更容易收集，并且存储和运输的成本更低，并且头发尼古丁比血液或尿液中的可替宁具有更长的暴露时间，但是与唾液可替宁相比，其实用性信息仍然有限。我们在巴尔的摩（美国马里兰州）对289名参与者（107名主动吸烟者，105名自我报告二手烟（SHS）暴露的被动吸烟者和77名没有SHS暴露的非吸烟者）进行了横断面研究。在两个月的时间间隔内，对一部分研究参与者（n = 52）进行了纵向随访。主动吸烟者，被动吸烟者和非吸烟者的基本头发尼古丁浓度中位数分别为16.2、0.36和0.23 ng / mg，而唾液可替宁的中位浓度分别为181.0、0.27和0.27 ng / mL。被动吸烟者或非吸烟者中10％的头发烟碱浓度高于主动吸烟者的25％百分位数，而他们所有相应的唾液可替宁浓度均低于主动吸烟者的百分位数。这项研究表明，头发尼古丁浓度值可用于区分主动吸烟者或被动吸烟者与未接触SHS的非吸烟者。我们的结果表明，头发尼古丁是评估长期暴露于烟草烟雾中的有用生物标志物。

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