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首页> 外文期刊>International Journal of Environmental Research and Public Health >Persistent HIV Viremia: Description of a Cohort of HIV Infected Individuals with ART Failure in Puerto Rico
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Persistent HIV Viremia: Description of a Cohort of HIV Infected Individuals with ART Failure in Puerto Rico

机译:持续性HIV病毒血症:在波多黎各接受ART失败的一组HIV感染者的描述

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The introduction of antiretroviral therapy (ART) has allowed human immunodeficiency virus (HIV) suppression in patients. We present data of a cohort of Puerto Rican patients with HIV who were under treatment with a steady regime of ART across a time horizon of eleven years. The time periods were categorized into four year stratums: 2000 to 2002; 2003 to 2005; 2006 to 2008 and 2009 to 2011. Socio-demographic profile, HIV risk factors, co-morbid conditions were included as study variables. One year mortality was defined. The p value was set at ≤0.05. The cohort consisted of 882 patients with 661 subjects presenting with persistent HIV viral load after a self-reported 12 month history of ART use. In this sub-cohort a higher viral load was seen across time (p < 0.05). Illicit drug use, IV drug use, alcohol use, loss of work were associated to having higher viral load means (p < 0.05). HIV viral load mean was lower as BMI increased (p < 0.001). It is imperative to readdress antiretroviral adherence protocols and further study ART tolerance and compliance.
机译:抗逆转录病毒疗法(ART)的引入已使患者能够抑制人类免疫缺陷病毒(HIV)。我们提供了波多黎各艾滋病毒患者队列的数据,这些患者在十一年的时间范围内一直接受稳定的抗逆转录病毒治疗。这些时间段分为四个层次:2000年至2002年;以及2000年至2002年。 2003年至2005年; 2006年至2008年以及2009年至2011年。社会人口统计学资料,HIV危险因素,合并症作为研究变量。确定了一年的死亡率。 p值设​​定为≤0.05。该队列包括882名患者,其中661名受试者在自我报告使用ART的12个月历史后表现出持续的HIV病毒载量。在该亚人群中,随着时间的推移,病毒载量更高(p <0.05)。非法使用毒品,静脉使用毒品,酗酒,丧失工作与较高的病毒载量均值相关(p <0.05)。随着BMI的增加,HIV病毒载量平均值较低(p <0.001)。必须解决抗逆转录病毒依从性方案,并进一步研究抗逆转录病毒的耐受性和依从性。

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