...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of General Medicine >Pilot study to explore the prophylactic efficacy of oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngo-tonsillar episodes in pediatric patients
【24h】

Pilot study to explore the prophylactic efficacy of oral probiotic Streptococcus salivarius K12 in preventing recurrent pharyngo-tonsillar episodes in pediatric patients

机译：探索口服益生菌唾液链球菌K12预防小儿患者反复咽扁桃体发作的预防功效的先导研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: In the pediatric population, acute pharyngo-tonsillitis represents one of the most frequent causes of access to outpatient treatment and use of antibiotics. In frequent tonsillitis, the pharmacological approach is no longer effective, and, therefore, surgery becomes the treatment of choice. Methods: This study compares the prophylactic efficacy of Streptococcus salivarius K12 (Bactoblissup?/sup) in children with recurrent pharyngo-tonsillitis treated vs untreated, with a 12 -month follow-up. The primary objectives are: The incidence of recurrence of pharyngo-tonsillar episodes and the concomitant use of other drugs. Secondary objectives are: tolerability of the treatment, the effectiveness in terms of clinical improvement, days of absence from school, reduction of the use of standard therapies, and cancellation from the surgical planning list. Results: Patients belonging to group A (treated with K12 for 90 days) were 24 males and 26 females, mean age 6.6 years (SD=1.57), those belonging to group B (untreated) were 23 males and 27 females, average age 6.8 years (SD=1.72). In the follow-up, group A reported 26 inflammatory pharyngo-tonsillary episodes in the first trimester, unlike group B, who reported 72 in the second trimester. This has shown a lower incidence (3.38%) of the disease compared to group B (6.66%), for a total of 169 inflammatory pharyngo-tonsillary episodes in group A against 333 in group B. A reduction in days of school absence of 429 days in group A and 927 days in the control group ( P 0.01) was also noted. Finally, 14 children of group A (28%) underwent adenotonsillectomy, against the whole group B. No adverse events were reported. Conclusion: The efficacy of K12 on the prevention of pharyngo-tonsillar infections, the decrease in the use of antibiotics and the improvement of the overall quality-of-life was confirmed, with a decreased number of absences from school and fewer patients undergoing surgery.
机译：背景：在儿科人群中，急性咽扁桃体炎是获得门诊治疗和使用抗生素的最常见原因之一。在频繁的扁桃体炎中，药理学方法不再有效，因此手术成为治疗的选择。方法：本研究比较了唾液链球菌K12（Bactoblis ？）对复发性咽扁桃体炎儿童与未治疗儿童的预防效果，并进行了12个月的随访。主要目标是：咽扁桃体发作的复发率以及同时使用其他药物。次要目标是：治疗的耐受性，临床改善的有效性，放学天数，减少标准疗法的使用以及从手术计划清单中删除。结果：A组（用K12治疗90天）的患者为男性24例，女性26例，平均年龄6.6岁（SD = 1.57），B组（未治疗）的患者为23例男性和27例女性，平均年龄6.8年（SD = 1.72）。在随访中，A组在孕早期报告了26例咽喉-扁桃体炎性发作，而B组在孕中期报告了72例。与B组（6.66％）相比，该病的发病率较低（3.38％），A组总共169例炎性咽-扁桃体炎发作较B组的333起。缺课天数减少429还注意到A组的天数和对照组的927天（P <0.01）。最后，针对整个B组，A组的14名儿童（28％）接受了腺扁桃体切除术。没有不良反应的报道。结论：证实了K12在预防咽扁桃体感染，减少抗生素使用和改善整体生活质量方面的功效，减少了缺课的次数，减少了接受手术的患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号