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Clinical differences between influenza A (H1N1) virus and respiratory infection between the two waves in 2009 and 2010

机译:2009年和2010年两波之间的甲型H1N1流感病毒和呼吸道感染之间的临床差异

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Background: The purpose of the present retrospective study was to examine the clinical differences between patients hospitalized with H1N1 virus and those hospitalized with nonvirus respiratory tract infection in 2009 and 2010.Methods: Adult patient data were collected from three tertiary hospital centers. Real-time reverse transcriptase polymerase chain reaction testing was used to confirm the diagnosis. We included 106 H1N1-positive patients (52 from 2009 and 54 from 2010). These data were compared with those from 108 patients with H1N1-negative respiratory tract infection (51 patients from 2009 and 57 from 2010).Results: In 2009, the mean age was 36.4 years for H1N1-positive patients versus 46.4 years for H1N1-negative patients, and mean body mass index (BMI) was 26.4 kg/m2 patients and 28.1 kg/m2, respectively. In 2009, seven patients required intubation, six of whom were H1N1-positive. In 2010, the mean age was 43.8 years for H1N1-positive patients versus 60.2 years for H1N1-negative patients, and mean BMI was 32.3 kg/m2 and 26.9 kg/m2, respectively. In 2010, six patients required intubation, three of whom were H1N1-positive. Abnormal chest x-ray findings were found significantly more frequently in H1N1-negative patients than in H1N1-positive patients.Conclusion: In comparison with 2009, H1N1-positive patients in 2010 were older, were more likely to be obese, and had more severe clinical and laboratory perturbations. However, this did not affect their outcomes. H1N1-negative patients were older in comparison with those who were H1N1-positive, and had more severe clinical and laboratory perturbations.
机译:背景:本回顾性研究的目的是研究2009年和2010年H1N1病毒住院患者和非病毒性呼吸道感染住院患者之间的临床差异。方法:从三个三级医院中心收集成人患者数据。实时逆转录酶聚合酶链反应测试用于确认诊断。我们纳入了106名H1N1阳性患者(2009年为52名,2010年为54名)。将这些数据与108例H1N1阴性呼吸道感染患者(2009年为51例,2010年为57例)进行了比较。结果:2009年,H1N1阳性患者的平均年龄为36.4岁,而H1N1阴性患者的平均年龄为46.4岁患者的平均体重指数(BMI)分别为26.4 kg / m2和28.1 kg / m2。 2009年,有7名患者需要插管,其中6名H1N1阳性。 2010年,H1N1阳性患者的平均年龄为43.8岁,而H1N1阴性患者的平均年龄为60.2岁,平均BMI分别为32.3 kg / m2和26.9 kg / m2。 2010年,有6名患者需要插管,其中3名H1N1阳性。结论:与2009年相比,2010年H1N1阳性患者年龄更大,更容易肥胖并且病情更重,与H1N1阳性患者相比,发现X线胸片异常的频率更高。临床和实验室干扰。但是,这并不影响他们的结果。与H1N1阳性的患者相比,H1N1阴性的患者年龄更大,并且在临床和实验室方面的干扰更为严重。

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