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首页> 外文期刊>International Journal of General Medicine >Autonomic dysfunction and primary antiphospholipid syndrome: a frequent and frightening correlation?
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Autonomic dysfunction and primary antiphospholipid syndrome: a frequent and frightening correlation?

机译：自主神经功能障碍和原发性抗磷脂综合征：频繁且令人恐惧的相关性？

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Introduction: the correlation between primary antiphospholipid syndrome (APS) and cardiovascular events is well known, but the correlation between APS and sudden death is not clear; it probably correlates with sympathetic alterations of the autonomic system.Aim: To compare the autonomic nervous system (ANS) in a group of subjects suffering from APS against that of a control group with no cardiovascular risk factors, matched for age, sex, and body mass index.Subjects and methods: An equal number (n = 31) of subjects with APS, and healthy controls, underwent autonomic evaluation: tilt test, deep breath, Valsalva maneuver, hand grip, lying-to-standing, Stroop, and sweat tests.Results: Cases in the APS group were positive for the tilt test, relating to changes in respiratory rate intervals, by comparison with controls. Results of other tests were also altered significantly in APS cases, by comparison with controls. (The sweat and Stroop tests were only performed in 14 cases). Autonomic disease did not correlate with age, sex, history of disease, arterial or venous thrombosis, or antibody positivity; only their coagulation parameters correlated with autonomic dysfunction.Conclusion: Autonomic dysfunction in APS seems to correlate with coagulation parameters. APS patients should receive autonomic evaluation, to minimize the risks of fatal arrhythmias and sudden death.
机译：简介：原发性抗磷脂综合症（APS）与心血管事件之间的相关性众所周知，但APS与猝死之间的相关性尚不清楚;目的：比较年龄，性别和身体相匹配的一组患有APS的受试者的自主神经系统（ANS）与无心血管危险因素的对照组的自主神经系统（ANS）。受试者和方法：相等数量（n = 31）的APS受试者和健康对照者进行了自主神经功能评估：倾斜测试，深呼吸，Valsalva动作，手握，躺着站立，Stroop和出汗结果：与对照组相比，APS组患者的倾斜测试呈阳性，与呼吸频率间隔的变化有关。与对照组相比，APS患者的其他检查结果也发生了显着变化。 （仅在14例中进行了汗液和Stroop测试）。自主神经疾病与年龄，性别，病史，动脉或静脉血栓形成或抗体阳性无关。结论：APS的自主神经功能异常似乎与凝血功能参数有关。 APS患者应接受自主评估，以最大程度地减少致命性心律失常和猝死的风险。

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