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首页> 外文期刊>International Journal of Environmental Research and Public Health >UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation
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UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation

机译：紫外线诱导卤代多环芳烃的光致脂质过氧化反应。

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Since the finding in the 1930s, a large number of polycyclic aromatic hydrocarbons (PAHs) of different structures have been tested for potential tumorigenicity. Structure-activity relationships of halo-PAHs have been investigated to determine the regions of a PAH that may be involved in cancer initiation. From these studies, a number of halo-PAHs were found to be tumorigenic in experimental animals. It was not until the 1980s that halo-PAHs were found to be present in the environment, including municipal incinerator fly ash, urban air, coal combustion, soil, snow, automobile exhausts, and tap water. Due to their widespread presence in the environment and their genotoxic activities, including carcinogenicity, many of these compounds may pose a health risk to humans. Although the biological activities, including metabolism, mutagenicity, and carcinogenicity, of halo-PAHs have been studied their phototoxicity and photo-induced biological activity have not been well examined. In this study, we study the photoirradiation of a series of structure-related halo-PAHs by UVA light in the presence of a lipid, methyl linoleate, and determine as to whether or not these compounds can induce lipid peroxidation. The halo-PAHs chosen for study include 2-bromonaphthalene, 1-chloroanthracene, 9,10-dibromoanthracene, 9-chlorophenanthrene, 9-bromophenanthrene, 7-chlorobenz[a]anthracene, 7-bromobenz[a]anthracene, 7-bromo-5-methylbenz[a]anthracene, 6-chlorobenzo[a]pyrene, and 6-bromobenzo[a]pyrene. The results indicate that upon photoirradiation by UVA all these compounds induced lipid peroxidation at different levels. These results suggest that halo-PAHs may be harmful to human health.
机译：自1930年代发现以来，已经测试了许多不同结构的多环芳烃（PAH）的潜在致瘤性。已经研究了卤素-PAHs的结构-活性关系，以确定可能参与癌症发作的PAH区域。从这些研究中，发现许多卤素-PAHs在实验动物中具有致瘤性。直到1980年代，才发现环境中存在卤代多环芳烃，包括市政焚化炉的飞灰，城市空气，煤炭燃烧，土壤，积雪，汽车尾气和自来水。由于它们在环境中的广泛存在及其遗传毒性活动（包括致癌性），这些化合物中的许多可能对人类构成健康风险。尽管已研究了卤代PAH的生物活性，包括代谢，诱变和致癌性，但其光毒性和光诱导的生物活性尚未得到很好的研究。在这项研究中，我们研究了在脂质，亚油酸甲酯的存在下，UVA光对一系列结构相关的卤代PAHs的光辐射，并确定了这些化合物是否可以诱导脂质过氧化。选择用于研究的卤代PAH包括2-溴萘，1-氯蒽，9,10-二溴蒽，9-氯菲，9-溴菲，7-氯苯[a]蒽，7-溴苯并[a]蒽，7-溴- 5-甲基苯并[a]蒽，6-氯苯并[a] py和6-溴苯并[a] py。结果表明，在用UVA光照射后，所有这些化合物均以不同水平诱导脂质过氧化。这些结果表明，卤代PAHs可能对人体健康有害。

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