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首页> 外文期刊>International Journal of Environmental Research and Public Health >Reliability of Urinary Excretion Rate Adjustment in Measurements of Hippuric Acid in Urine
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Reliability of Urinary Excretion Rate Adjustment in Measurements of Hippuric Acid in Urine

机译：尿中马尿酸测定中尿排泄率调节的可靠性

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摘要

The urinary excretion rate is calculated based on short-term, defined time sample collections with a known sample mass, and this measurement can be used to remove the variability in urine concentrations due to urine dilution. Adjustment to the urinary excretion rate of hippuric acid was evaluated in 31 healthy volunteers (14 males and 17 females). Urine was collected as short-term or spot samples and tested for specific gravity, creatinine and hippuric acid. Hippuric acid values were unadjusted or adjusted to measurements of specific gravity, creatinine or urinary excretion rate. Hippuric acid levels were partially independent of urinary volume and urinary flow rate, in contrast to specific gravity and creatinine, which were both highly dependent on the hippuric acid level. Accordingly, hippuric acid was independent on urinary specific gravity and creatinine excretion. Unadjusted and adjusted values for specific gravity or creatinine were generally closely correlated, especially in spot samples. Values adjusted to the urinary excretion rate appeared well correlated to those unadjusted and adjusted to specific gravity or creatinine values. Thus, adjustment of crude hippuric acid values to the urinary excretion rate is a valid procedure but is difficult to apply in the field of occupational medicine and does not improve the information derived from values determined in spot urine samples, either unadjusted or adjusted to specific gravity and creatinine.
机译：尿液排泄率是根据具有已知样品质量的短期，限定时间的样品采集计算得出的，该测量结果可用于消除由于尿液稀释而导致的尿液浓度变化。在31名健康志愿者（男性14位，女性17位）中评估了对马尿酸尿排泄率的调整。收集尿液作为短期或现场样本，并测试其比重，肌酐和马尿酸。未调整马尿酸值或将其调整为比重，肌酐或尿排泄率的测量值。与比重和肌酐相反，马尿酸水平部分地独立于尿量和尿流率，这两者都高度依赖于马尿酸水平。因此，马尿酸与尿比重和肌酐排泄无关。通常未比重和比重或肌酐的调整值密切相关，尤其是在现场样品中。调整为尿排泄率的值似乎与未调整并调整为比重或肌酐值的相关性很好。因此，将粗制马尿酸值调整为尿排泄率是一种有效程序，但很难在职业医学领域应用，并且不能改善从现场尿液样品中确定的值（未经调整或已调整至比重）得出的信息和肌酐。

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