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首页> 外文期刊>International Journal of Environmental Research and Public Health >PM2.5 and Cardiovascular Diseases in the Elderly: An Overview
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PM2.5 and Cardiovascular Diseases in the Elderly: An Overview

机译：PM2.5与老年人心血管疾病：概述

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摘要

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in the elderly and the ambient concentration of PM2.5 has been associated with several cardiovascular diseases. Methods: We describe the present state of planetary air pollution, analyze epidemiological studies linking PM2.5 and CVD, and discuss multiple pathophysiological mechanisms linking PM2.5 and CVD. Results: A few epidemiological studies show that the elderly appear specifically susceptible to adverse cardiovascular effects triggered by PM2.5 exposure. Plausible pathophysiological mechanisms include inflammatory dysfunction, oxidative stress, abnormal activation of the hemostatic system and disturbance of the autonomic nervous system. Conclusions: An in-depth knowledge of the chemical compounds, pathophysiological mechanisms, and epidemiological studies of PM2.5 are recommended to understand this important and modifiable factor contributing to geriatric CVD burden. We offer public health recommendations to reduce this preventable cause of disease and death.
机译：心血管疾病（CVD）是老年人死亡和发病的主要原因，环境中PM2.5的浓度已与多种心血管疾病相关。方法：我们描述了行星空气污染的现状，分析了与PM2.5和CVD相关的流行病学研究，并讨论了与PM2.5和CVD相关的多种病理生理机制。结果：一些流行病学研究表明，老年人似乎特别容易受到PM2.5暴露引发的不良心血管影响。可能的病理生理机制包括炎性功能障碍，氧化应激，止血系统异常激活和自主神经系统紊乱。结论：建议深入了解PM2.5的化合物，病理生理机制和流行病学研究，以了解导致老年CVD负担的这一重要且可修改的因素。我们提供公共健康建议，以减少这种可预防的疾病和死亡原因。

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