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首页> 外文期刊>International Journal of General Medicine >Mitochondrial disorder caused Charles Darwin's cyclic vomiting syndrome
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Mitochondrial disorder caused Charles Darwin's cyclic vomiting syndrome

机译：线粒体疾病引起查尔斯·达尔文周期性呕吐综合征

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Background: Charles Darwin (CD), “father of modern biology,” suffered from multisystem illness from early adulthood. The most disabling manifestation was cyclic vomiting syndrome (CVS). This study aims at finding the possible cause of CVS in CD.Methods: A literature search using the PubMed database was carried out, and CD's complaints, as reported in his personal writings and those of his relatives, friends, colleagues, biographers, were compared with various manifestations of mitochondrial disorders (MIDs), known to cause CVS, described in the literature.Results: Organ tissues involved in CD's disease were brain, nerves, muscles, vestibular apparatus, heart, gut, and skin. Cerebral manifestations included episodic headache, visual disturbance, episodic memory loss, periodic paralysis, hysterical crying, panic attacks, and episodes of depression. Manifestations of polyneuropathy included numbness, paresthesias, increased sweating, temperature sensitivity, and arterial hypotension. Muscular manifestations included periods of exhaustion, easy fatigability, myalgia, and muscle twitching. Cardiac manifestations included episodes of palpitations and chest pain. Gastrointestinal manifestations were CVS, dental problems, abnormal seasickness, eructation, belching, and flatulence. Dermatological manifestations included painful lips, dermatitis, eczema, and facial edema. Treatments with beneficial effects to his complaints were rest, relaxation, heat, and hydrotherapy.Conclusion: CVS in CD was most likely due to a multisystem, nonsyndromic MID. This diagnosis is based upon the multisystem nature of his disease, the fact that CVS is most frequently the manifestation of a MID, the family history, the variable phenotypic expression between affected family members, the fact that symptoms were triggered by stress, and that only few symptoms could not be explained by a MID.
机译：背景：“现代生物学之父”查尔斯·达尔文（CD）自成年后就患有多系统疾病。最致残的表现是循环性呕吐综合征（CVS）。本研究旨在发现CD中CVS的可能原因。方法：使用PubMed数据库进行文献搜索，比较CD在他的个人著作中以及他的亲戚，朋友，同事，传记作者的抱怨。文献中描述了各种形式的线粒体疾病（MID），已知会导致CVS。结果：与CD疾病有关的器官组织是大脑，神经，肌肉，前庭器官，心脏，肠道和皮肤。脑部表现包括发作性头痛，视觉障碍，发作性记忆丧失，周期性麻痹，歇斯底里的哭泣，惊恐发作和抑郁发作。多发性神经病的表现包括麻木，感觉异常，出汗增加，温度敏感性和动脉低血压。肌肉表现包括疲惫，易疲劳，肌痛和肌肉抽搐。心脏表现包括心发作和胸痛。胃肠道表现为CVS，牙齿问题，晕船，肠胃不适，气和肠胃气胀。皮肤病学表现包括嘴唇疼痛，皮炎，湿疹和面部浮肿。对他的主诉有益的治疗方法是休息，放松，加热和水疗。结论：CD中的CVS最有可能是由于多系统，非综合征性MID所致。该诊断基于他的疾病的多系统性质，以下事实：CVS最常是MID的表现，家族史，受影响的家庭成员之间的可变表型表达，症状是由压力触发的事实，并且仅MID无法解释很少的症状。

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