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首页> 外文期刊>International Journal of General Medicine >Effects of laparoscopic adjustable gastric banding on sleep and metabolism: a 12-month follow-up study
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Effects of laparoscopic adjustable gastric banding on sleep and metabolism: a 12-month follow-up study

机译：腹腔镜可调节胃束带对睡眠和代谢的影响：一项为期12个月的随访研究

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Background: Obstructive sleep apnea is commonly associated with metabolic changes and obesity, and changes in body weight by either medical or surgical approaches have been considered to affect the severity of sleep apnea and appetite-controlling hormones. This prospective study evaluated the effect of weight loss induced by laparoscopic adjustable gastric banding (LAGB) surgery on respiratory disturbance during sleep, oxygen saturation levels, sleep architecture, and leptin and ghrelin levels.Methods: Participants were patients at a university-based medical center surgical weight loss program. All participants with a body mass index > 30 kg/m2 undergoing LAGB surgery for weight reduction were offered the opportunity to participate in the study. Procedures included overnight polysomnography followed by fasting hormone levels at baseline and 12 months postoperatively.Results: Thirty subjects (10 men, 20 women) of mean age 44.0 ± 12.5 years were recruited. At 12 months postoperatively, mean excess weight loss was 44.4% ± 14%. The apnea-hypopnea index decreased from 34.2 ± 35 to 19.0 ± 21.7 events per hour (P < 0.0001), while leptin levels decreased from 24.5 ± 17.42 pg/mL to 11.6 ± 10.6 pg/mL (P = 0.02). Ghrelin levels did not change substantially. Nadir oxygen saturation levels increased from 81% to 84% at 12 months (P = 0.03). Mean oxygen saturation improved and was positively correlated with ghrelin levels at both time points (r = 0.39, P = 0.07, and r = 0.60, P = 0.01).Conclusion: LAGB surgery was associated with 44.4% excess weight loss at 12 months, accompanied by a 33.7% improvement in apnea-hypopnea index as well as a reduction in leptin levels by 31.7% in this group. An association between ghrelin and mean oxygen saturation was seen and deserves further investigation.
机译：背景：阻塞性睡眠呼吸暂停通常与代谢变化和肥胖症相关，通过医学或手术方法引起的体重变化已被认为会影响睡眠呼吸暂停和控制食欲的激素的严重程度。这项前瞻性研究评估了腹腔镜可调胃绑带术（LAGB）引起的减肥对睡眠期间呼吸系统疾病，血氧饱和度，睡眠结构以及瘦素和生长素释放肽水平的影响。方法：参与者是大学医疗中心的患者外科减肥计划。所有体重指数> 30 kg / m2的接受LAGB手术以减轻体重的参与者均获得参与该研究的机会。程序包括通宵多导睡眠图检查，然后在基线和术后12个月禁食激素水平。结果：招募了30名平均年龄44.0±12.5岁的受试者（10名男性，20名女性）。术后12个月，平均体重减轻为44.4％±14％。呼吸暂停低通气指数从每小时34.2±35下降至19.0±21.7事件（P <0.0001），而瘦素水平从24.5±17.42 pg / mL下降至11.6±10.6 pg / mL（P = 0.02）。生长激素释放肽水平没有实质性变化。在12个月时，最低点的氧饱和度水平从81％增加到84％（P = 0.03）。平均氧饱和度在两个时间点均得到改善并与生长素释放肽水平呈正相关（r = 0.39，P = 0.07，r = 0.60，P = 0.01）。结论：LAGB手术在12个月时体重减轻44.4％，该组患者的呼吸暂停低通气指数提高了33.7％，瘦素水平降低了31.7％。 ghrelin与平均氧饱和度之间存在关联，值得进一步研究。

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