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首页> 外文期刊>International Journal of General Medicine >Nadir CD4+, religion, antiretroviral therapy, incidence of type 2 diabetes mellitus, and increasing rates of obesity among black Africans with HIV disease
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Nadir CD4+, religion, antiretroviral therapy, incidence of type 2 diabetes mellitus, and increasing rates of obesity among black Africans with HIV disease

机译：最低点CD4 +，宗教信仰，抗逆转录病毒疗法，2型糖尿病的发生率以及患有HIV疾病的黑人非洲人肥胖率上升

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Background: The purpose of this study was to determine the cross-sectional association between some sociodemographic factors and antiretroviral therapy (ART), as well as the incidence and predictors of type 2 diabetes mellitus among Central Africans with human immunodeficiency virus (HIV) disease.Methods: This study had a cross-sectional design and was a prospective analysis of 102 patients with HIV disease (49 on ART versus 53 not on ART) in Kinshasa, Democratic Republic of Congo, between 2004 and 2008. A Cox regression model was used to assess for any relationship between type 2 diabetes and exposure to combination ART without protease inhibitors, after adjusting for known risk factors for type 2 diabetes, nadir CD4 and CD8 levels, viral load, marital status, and religion.Results: Unexpectedly elevated rates of smoking, excess alcohol intake, and ART-related total, abdominal, and peripheral obesity were observed in our study group of HIV patients. At the end of follow-up, five patients were diagnosed with type 2 diabetes (incidence rate 4.9%, 9.8 per 1000 person-years). Univariate risk factors for type 2 diabetes were male gender (relative risk [RR] 1.1, 95% confidence interval [CI] 1.01–1.4; P = 0.019), traditional religion versus new charismatic religion (RR 1.1, 95% CI 1.01–1.3; P = 0.046), exposure to ART (RR 1.1, 95% CI 1.002–1.3; P = 0.034), and single status (RR 6.2, 95% CI 1.5–15; P = 0.047). In multivariate analysis, strong significant independent predictors of type 2 diabetes were belonging to a traditional religion (HR 2.1, 95% CI 1.1–4.2; P = 0.036) and a relative increase in nadir CD4 cell count (beta coefficient 0.003; P < 0.0001).Conclusion: ART-related obesity and type 2 diabetes are becoming increasing problems in Central Africans with HIV disease. A relative increase in nadir CD4 count and traditional religion status appear to be the strongest independent predictors of type 2 diabetes.
机译：背景：本研究的目的是确定某些社会人口统计学因素与抗逆转录病毒疗法（ART）之间的横断面关联，以及中非裔人免疫缺陷病毒（HIV）疾病中2型糖尿病的发生率和预测指标。方法：本研究采用横断面设计，是对2004年至2008年之间在刚果民主共和国金夏沙的102例HIV感染者（前接受抗病毒治疗的49位患者，未接受抗病毒治疗的53位患者）进行的前瞻性分析。使用了Cox回归模型在调整了已知的2型糖尿病的危险因素，最低的CD4和CD8水平，病毒载量，婚姻状况和宗教信仰之后，评估2型糖尿病与暴露于无蛋白酶抑制剂的联合抗逆转录病毒疗法之间的任何关系。在我们的HIV患者研究小组中，观察到吸烟，过量饮酒以及与ART相关的总体肥胖，腹部肥胖和外周肥胖。随访结束时，有五名患者被诊断出患有2型糖尿病（发生率4.9％，每1000人年9.8）。 2型糖尿病的单因素风险因素是男性（相对风险[RR] 1.1，95％置信区间[CI] 1.01–1.4; P = 0.019），传统宗教与新魅力宗教（RR 1.1，95％CI 1.01–1.3） ; P = 0.046），ART暴露（RR 1.1，95％CI 1.002–1.3; P = 0.034）和单身状态（RR 6.2，95％CI 1.5-15; P = 0.047）。在多变量分析中，2型糖尿病的重要的重要独立预测因素属于传统宗教（HR 2.1，95％CI 1.1–4.2; P = 0.036）和最低点CD4细胞计数相对增加（β系数0.003; P <0.0001）结论：与ART相关的肥胖症和2型糖尿病在中部非洲艾滋病毒感染者中正成为日益严重的问题。最低点CD4计数和传统宗教状况的相对增加似乎是2型糖尿病的最强独立预测因子。

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