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首页> 外文期刊>International Journal of General Medicine >Update on the clinical utility and optimal use of cefditoren
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Update on the clinical utility and optimal use of cefditoren

机译：头孢托仑的临床实用性和最佳使用的最新进展

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Abstract: This article reviews and updates published data on cefditoren. The in vitro activity of cefditoren and its potential pharmacokinetic/pharmacodynamic adequacy to cover emerging resistance phenotypes in the present decade is reviewed. Cefditoren's in vitro activity against most prevalent bacterial respiratory pathogens in the community and its pharmacokinetic/pharmacodynamic profile suggests a significant role for cefditoren in the treatment of respiratory tract infections. Clinical trials (in acute exacerbations of chronic bronchitis, community-acquired pneumonia, pharyngotonsillitis, and sinusitis) performed during clinical development outside Japan, mainly in adults, are reviewed, together with new clinical studies in the treatment of pharyngotonsillitis, sinusitis, and otitis media in children, mainly in Japan, for efficacy and safety assessment. The results of these studies support the adequacy of cefditoren for the treatment of community-acquired respiratory tract infections with a safety profile similar to previous oral antibiotics. From the data reviewed, it is concluded that cefditoren is an adequate option for the treatment of mild-to-moderate community-acquired respiratory infections, especially in geographical areas with a reported prevalence of phenotypes exhibiting nonsusceptibility to common oral antibiotics.
机译：摘要：本文评论并更新了有关头孢托仑的公开数据。本文综述了头孢托仑的体外活性及其潜在的药代动力学/药效学足够性，以涵盖最近十年来出现的耐药性表型。头孢妥伦对社区中最普遍的细菌性呼吸道病原体的体外活性及其药代动力学/药效学特征表明，头孢妥伦在呼吸道感染的治疗中起着重要作用。回顾了在日本以外的临床开发阶段（主要在成年人中进行的临床试验（在慢性支气管炎，社区获得性肺炎，咽炎和鼻窦炎的急性加重中），以及治疗咽喉炎，鼻窦炎和中耳炎的新临床研究。对儿童（主要在日本）进行疗效和安全性评估。这些研究的结果支持头孢托仑足以治疗社区获得性呼吸道感染，其安全性与以前的口服抗生素相似。从数据审查，得出的结论是头孢是轻度至中度社区获得性呼吸道感染的治疗充足的选择，尤其是在与参展nonsusceptibility常见的口服抗生素表型的发病率为地理区域。

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