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首页> 外文期刊>International Journal of General Medicine >Effect of fluid loading with normal saline and 6% hydroxyethyl starch on stroke volume variability and left ventricular volume
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Effect of fluid loading with normal saline and 6% hydroxyethyl starch on stroke volume variability and left ventricular volume

机译：生理盐水和6％羟乙基淀粉对液体负荷的影响对卒中容量变异性和左心室容量的影响

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Purpose: The aim of this clinical trial was to investigate changes in stroke volume variability (SVV) and left ventricular end-diastolic volume (LVEDV) after a fluid bolus of crystalloid or colloid using real-time three-dimensional transesophageal echocardiography (3D-TEE) and the Vigileo-FloTrac? system.Materials and methods: After obtaining Institutional Review Board approval, and informed consent from the research participants, 22 patients undergoing scheduled peripheral vascular bypass surgery were enrolled in the study. The patients were randomly assigned to receive 500 mL of hydroxyethyl starch (HES; HES group, n=11) or normal saline (Saline group, n=11) for fluid replacement therapy. SVV was measured using the Vigileo-FloTrac system. LVEDV, stroke volume, and cardiac output were measured by 3D-TEE. The measurements were performed over 30 minutes before and after the fluid bolus in both groups.Results: SVV significantly decreased after fluid bolus in both groups (HES group, 14.7%±2.6% to 6.9%±2.7%, P0.05). Stroke volume significantly increased after infusion in the HES group (50.6±12.5 mL to 61.6±19.1 mL, P0.05). Cardiac output measured by 3D-TEE significantly increased in the HES group (3.5±1.1 L/min to 3.9±1.3 L/min, P0.05).Conclusion: Administration of colloid and crystalloid induced similar responses in SVV. A higher plasma-expanding effect of HES compared to normal saline was demonstrated by the significant increase in LVEDV.
机译：目的：该临床试验的目的是使用实时三维经食道超声心动图（3D-TEE）研究晶体或胶体液体推注后的卒中体积变异性（SVV）和左室舒张末期体积（LVEDV）的变化。 ）和Vigileo-FloTrac？系统和研究方法：材料和方法：在获得机构审查委员会的批准并获得研究参与者的知情同意后，将22名接受计划的外周血管搭桥手术的患者纳入研究。患者被随机分配接受500 mL羟乙基淀粉（HES; HES组，n = 11）或生理盐水（盐水组，n = 11）进行补液治疗。 SVV使用Vigileo-FloTrac系统进行测量。 LVEDV，中风量和心输出量通过3D-TEE测量。两组均在推注前后30分钟进行测量。结果：两组均在推注后SVV明显降低（HES组，分别为14.7％±2.6％至6.9％±2.7％，P0.05）。 HES组输注后中风量显着增加（50.6±12.5 mL至61.6±19.1 mL，P0.05）。 HES组通过3D-TEE测量的心输出量显着增加（3.5±1.1 L / min至3.9±1.3 L / min，P0.05）。结论：胶体和晶体的给药在SVV中引起相似的反应。 LVEDV的显着增加表明，与生理盐水相比，HES具有更高的血浆扩张作用。

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