...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of General Medicine >Tumor necrosis factor alpha as a marker of systemic and local inflammation in “healthy” smokers
【24h】

Tumor necrosis factor alpha as a marker of systemic and local inflammation in “healthy” smokers

机译：肿瘤坏死因子α是“健康”吸烟者全身和局部炎症的标志

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Tobacco smoking induces a local and systemic inflammatory reaction and also a decline in pulmonary function. There are some novel noninvasive methods to measure the degree of inflammatory bronchial reaction, including the exhaled breath condensate (EBC) in which several inflammatory markers can be measured, including tumor necrosis factor alpha (TNF-α). There is a clear clinical need to develop methods that allow early detection of smokers at risk of losing pulmonary function.Objectives: The aims of the present study are: 1) to show that smokers show higher levels of TNF-α both in serum and EBC; 2) to analyze the possible influence of gender, age, and weight on this parameter; and 3) to determine a possible association between smoking and pulmonary function parameters and TNF-α levels.Material and methods: We have prospectively analyzed two cohorts of smokers and nonsmokers subjects without any chronic or acute disease (within eight weeks of study initiation). We have performed pulmonary function tests with bronchodilators and also collected EBC and blood samples before smoking cessation. Statistical analysis was performed with SPSS 11.0 for Windows Statistical Package.Results: The study has enrolled 17 patients (8 smokers), 50% of whom were females. Mean age was 38.59 years old (standard deviation, 7.4). The mean number of cigarettes smoked in the smoker group was 26.14 (11.29) cigarettes/day and the mean age when tobacco first began was 15.14 (2.04) years. We have not been able to show any significant differences in TNF-α levels according to age or weight. For the whole series we have not found any significant influence of gender in TNF-α levels, but after dividing the series in smokers and nonsmokers, we have shown higher levels of TNF-α in serum (5.59 [0.26] pg/mL vs 5.56 [0.37] pg/mL; nonsignificant [NS]) and EBC (4.94 [0.41] pg/mL vs 4.22 [0.36] pg/mL; p = 0.031) in male smokers. On the other hand, nonsmoking females showed slightly higher TNF-α levels in serum (5.70 [0.50] pg/mL vs 5.42 [0.29] pg/mL; NS) and EBC (4.54 [0.92] vs 4.11 [0.41 pg/mL]; NS). Smokers had higher TNF-α levels in EBC (4.46 [0.58] pg/mL vs 4.34 [0.62] pg/mL; NS), while serum TNF-α levels were slightly higher in nonsmokers (5.52 [0.56] pg/mL vs 5.50 [0.27] pg/mL; NS). We have not demonstrated any association between tobacco consumption and TNF-α levels. We have not shown any significant relation between pulmonary function and the studied parameters, with only a modest association between forced expiratory volume at one second and forced vital capacity and TNF-α levels in EBC.Conclusion: Smokers show higher TNF-α levels in EBC. Among smokers, males show higher levels of TNF in serum and EBC. We have not confirmed any significant influence of age or weight on TNF-α levels. These levels do not seem to be influenced either by the amount of tobacco or the time since habit began. We have shown a modest relation between pulmonary function and TNF-α levels in EBC.
机译：背景：吸烟会引起局部和全身性炎症反应，还会导致肺功能下降。有一些新的非侵入性方法可以测量炎症性支气管反应的程度，包括呼出气凝结液（EBC），其中可以测量多种炎症标记，包括肿瘤坏死因子α（TNF-α）。目的：本研究的目的是：1）证明吸烟者在血清和EBC中均显示较高的TNF-α水平，因此，临床上显然需要开发一种方法，以早期发现有肺功能丧失风险的吸烟者。 ; 2）分析性别，年龄和体重对该参数的可能影响;和3）确定吸烟和肺功能参数与TNF-α水平之间可能存在的联系。材料和方法：我们前瞻性分析了两个吸烟者和非吸烟者队列，未发现任何慢性或急性疾病（在研究开始的八周内）。我们已经使用支气管扩张药进行了肺功能检查，并且在戒烟之前也收集了EBC和血液样本。使用Windows统计软件包的SPSS 11.0进行统计分析。结果：该研究招募了17位患者（8位吸烟者），其中50％是女性。平均年龄为38.59岁（标准差为7.4）。吸烟者组中吸烟的平均香烟数为每天26.14（11.29）支香烟，而首次吸烟的平均年龄为15.14（2.04）岁。根据年龄或体重，我们未能显示出TNF-α水平的任何显着差异。对于整个系列，我们并未发现性别对TNF-α水平有任何显着影响，但是在将系列划分为吸烟者和非吸烟者后，我们显示血清中的TNF-α水平更高（5.59 [0.26] pg / mL vs 5.56男性吸烟者中[0.37] pg / mL;无显着性[NS]）和EBC（4.94 [0.41] pg / mL与4.22 [0.36] pg / mL; p = 0.031）。另一方面，不吸烟的女性在血清中的TNF-α水平略高（5.70 [0.50] pg / mL对5.42 [0.29] pg / mL; NS）和EBC（4.54 [0.92]对4.11 [0.41 pg / mL]） ; NS）。吸烟者的EBC中TNF-α水平较高（4.46 [0.58] pg / mL对4.34 [0.62] pg / mL; NS），而非吸烟者的血清TNF-α水平则稍高（5.52 [0.56] pg / mL对5.50 [0.27] pg / mL; NS）。我们尚未证明烟草消费与TNF-α水平之间有任何关联。我们还没有显示出肺功能与研究参数之间的任何显着关系，仅一秒钟的强迫呼气量和强迫肺活量与EBC中的TNF-α水平之间存在适度的关系。结论：吸烟者在EBC中显示较高的TNF-α水平。在吸烟者中，男性血清和EBC中的TNF水平较高。我们尚未证实年龄或体重对TNF-α水平有任何重大影响。这些水平似乎不受烟草数量或习惯开始后的时间的影响。我们显示了EBC中肺功能与TNF-α水平之间的适度关系。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号