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首页> 外文期刊>International Journal of Hypertension >Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat
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Circadian Variations in Blood Pressure, Heart Rate, and HR-BP Cross-Correlation Coefficient during Progression of Diabetes Mellitus in Rat

机译：大鼠糖尿病发展过程中血压，心率和HR-BP互相关系数的昼夜变化

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Circadian changes in cardiovascular function during the progression of diabetes mellitus in the diabetes prone rat (BBDP) (n=8) were studied. Age-matched diabetes-resistant rats (BBDR) served as controls. BP was recorded via telemetry in contiguous 4 hr time periods over 24 hours starting with 12 midnight to 4 am as period zero (P0). Prior to onset of diabetes BP was high at P0, peaked at P2, and then fell again at P3; BP and heart rate (HR) then increased gradually at P4 and leveled off at P5, thereby exhibiting a bipodal rhythm. These patterns changed during long-term diabetes. The cross-correlation coefficient of BP and HR was not significantly different across groups at onset, but it fell significantly at 9 months of duration of diabetes (BBDP: 0.39 ± 0.06; BBDR: 0.65 ± 0.03;P<.05). These results show that changes in circadian cardiovascular rhythms in diabetes mellitus became significant at the late stage of the disease.
机译：研究了糖尿病易感大鼠（BBDP）（n = 8）在糖尿病进展过程中昼夜节律的变化。年龄匹配的糖尿病抗性大鼠（BBDR）作为对照。通过遥测技术在连续24小时的4小时内，从午夜12点至凌晨4点（零时间）开始记录BP（P0）。在糖尿病发作之前，BP在P0高，在P2达到峰值，然后在P3再次下降。然后，血压和心率（HR）在P4逐渐升高，在P5趋于平稳，从而表现出双足节律。在长期糖尿病期间，这些模式发生了变化。发病时各组之间的BP和HR互相关系数无显着差异，但在糖尿病持续时间为9个月时显着下降（BBDP：0.39±0.06; BBDR：0.65±0.03; P <.05）。这些结果表明，糖尿病的昼夜节律改变在该疾病的晚期变得很重要。

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