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首页> 外文期刊>International Journal of Hepatology >Role of Adaptive Immunity in Alcoholic Liver Disease
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Role of Adaptive Immunity in Alcoholic Liver Disease

机译：适应性免疫在酒精性肝病中的作用

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Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis. Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized. Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines. Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents. In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients. Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD.
机译：人们日益认识到，先天免疫的刺激在酒精性肝病（ALD）的发病机理中起着重要作用，而适应性免疫的作用却很少受到关注。临床和实验数据表明Th-1和Th-17 T淋巴细胞与酒精性肝炎有关。但是，酒精触发适应性免疫的机制仍不完全清楚。患有晚期ALD的患者具有循环的IgG和T淋巴细胞，它们识别由羟乙基自由基和脂质过氧化终产物修饰的蛋白质所产生的表位。抗脂质过氧化衍生的抗原的高滴度IgG与肝脏促炎性细胞因子/趋化因子的产生增加有关。此外，相同的抗原有助于打破对肝成分的自我耐受性。特别是，在部分ALD患者中明显存在针对细胞色素P4502E1（CYP2E1）的自身抗体。总而言之，这些结果表明由氧化应激触发的同种和自身免疫反应可能在ALD的发展过程中助长了肝脏炎症。

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