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首页> 外文期刊>International Journal of Hepatology >Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease
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Paraoxonase Activity and Expression Is Modulated by Therapeutics in Experimental Rat Nonalcoholic Fatty Liver Disease

机译：对氧磷酶的活性和表达受治疗性实验性非酒精性脂肪性肝病的调节

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Objective. The objective of the present study is to investigate the effect of rosiglitazone, metformin, ezetimibe, and valsartan (alone or in combinations) on paraoxonase (PON) activity and PON-mRNA expression in nonalcoholic fatty liver disease (NAFLD).Methods. 54 Male Sprague–Dawley rats were divided to 9 groups: chow diet group (15 weeks); methionine-choline-deficient diet (MCDD) group (15 weeks); MCDD-treated groups for the last 6 weeks with either metformin (M), rosiglitazone (R), metformin plus rosiglitazone (M+R), ezetimibe (E), valsartan (V), or a combination of R+M+V or of R+M+V+E for a total period of 15 weeks.Results. PON activities in serum and liver were decreased in MCDD rats. PON activity in serum increased significantly in all treatment groups. PON activity in liver was also increased significantly, except only in groups R, E, V, R+M+V, and R+M+V+E. Liver PON3 mRNA expression increased significantly in groups R+M, E, V, R+M+V, and R+M+V+E whereas liver PON2 mRNA expression increased significantly in MCDD, R+M, E, V, R+M+V, and R+M+V+E.Conclusions. PON activities in serum and liver were decreased in NAFLD. Treatment with insulin sensitizers, ezetimibe, and valsartan increased PON activity and reduced oxidative stress both in serum and liver.
机译：目的。本研究的目的是研究罗格列酮，二甲双胍，依折麦布和缬沙坦（单独或组合使用）对非酒精性脂肪肝疾病（NAFLD）中对氧磷酶（PON）活性和PON-mRNA表达的影响。将54只雄性Sprague-Dawley大鼠分为9组：低脂饮食组（15周）;低脂饮食组（15周）;低脂饮食组（15周）。甲硫氨酸-胆碱缺乏饮食（MCDD）组（15周）;在过去6周内接受二甲双胍（M），罗格列酮（R），二甲双胍加罗格列酮（M + R），依折麦布（E），缬沙坦（V）或R + M + V的组合治疗的MCDD组R + M + V + E的总时间为15周。 MCDD大鼠血清和肝脏的PON活性降低。在所有治疗组中，血清中的PON活性均显着增加。除R，E，V，R + M + V和R + M + V + E组外，肝脏中的PON活性也显着增加。 R + M，E，V，R + M + V和R + M + V + E组肝PON3 mRNA表达显着增加，而MCDD，R + M，E，V，R +组肝PON2 mRNA表达显着增加M + V和R + M + V + E。结论。在NAFLD中，血清和肝脏中的PON活性降低。用胰岛素增敏剂，依泽替米贝和缬沙坦治疗可增加PON活性并降低血清和肝脏的氧化应激。

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