• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Chronic Diseases >Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions
【24h】

Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions

机译：血清铁蛋白在炎性疾病中诊断铁缺乏症的局限性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating the diagnosis. Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites. Patients with inflammatory conditions may thus have restricted availability of iron for erythropoiesis and other cell functions due to increased hepcidin expression, despite normal or high levels of serum ferritin. The standard threshold for iron deficiency (<30 μg/L) therefore does not apply and transferrin saturation (TSAT), a marker of iron availability, should also be assessed. A serum ferritin threshold of <100 μg/L or TSAT < 20% can be considered diagnostic for iron deficiency in CHF, CKD, and IBD. If serum ferritin is 100–300 μg/L, TSAT < 20% is required to confirm iron deficiency. Routine surveillance of serum ferritin and TSAT in these at-risk groups is advisable so that iron deficiency can be detected and managed.
机译：患有炎症性疾病（例如，炎症性肠病（IBD），慢性心力衰竭（CHF）和慢性肾脏病（CKD））的患者铁缺乏症的发生率很高，具有不良的临床后果。在正常情况下，血清铁蛋白水平是铁状态的敏感指标，但铁蛋白是一种急性期反应物，随着炎症反应而升高，使诊断复杂化。促炎性细胞因子也触发铁调素的增加，这限制了饮食中铁的吸收，并促进铁蛋白在储存位点的螯合。尽管血清铁蛋白水平正常或很高，但由于炎症因子表达增加，患有炎症性疾病的患者仍可能限制铁用于红细胞生成和其他细胞功能。因此，铁缺乏症的标准阈值（<30μg/ L）不适用，还应评估铁的可利用性指标转铁蛋白饱和度（TSAT）。血清铁蛋白阈值<100μg/ L或TSAT <20％可被认为可诊断CHF，CKD和IBD中的铁缺乏症。如果血清铁蛋白为100–300μg / L，则需要TSAT <20％才能确认铁缺乏。建议对这些高危人群进行血清铁蛋白和TSAT的常规监测，以便可以检测和处理铁缺乏症。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号