...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Hepatology >Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease
【24h】

Relationship between Serum Cytokeratin-18, Control Attenuation Parameter, NAFLD Fibrosis Score, and Liver Steatosis in Nonalcoholic Fatty Liver Disease

机译：非酒精性脂肪肝患者血清细胞角蛋白-18，控制衰减参数，NAFLD纤维化评分和肝脂肪变性之间的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Backgrounds. The aim of this study was to appraise the relationship between serum fragmented cytokeratin-18(CK-18), controlled attenuation parameter (CAP), and liver steatosis assessed by ultrasound (US) in nonalcoholic fatty liver disease (NAFLD) patients. Methods. Patients who underwent abdominal US were recruited, followed with measurement of CAP using Fibroscan? and serum fragmented CK-18 using enzyme-linked immunosorbent assay. The degree of liver steatosis assessed by US was categorized into mild (S1), moderate (S2), and severe (S3). Results. A total of 109 patients were included in our study. CAP and fragmented CK-18 level were significantly correlated with liver steatosis grade with rs = 0.56 and 0.68, p=0.001, respectively. NAFLD Fibrosis Score was poorly correlated with liver steatosis grade (=-0.096, p=0.318). Using fragmented CK-18 level, area under receiver operating characteristic (AUROC) curves for S≥2 and S≥3 were excellent (0.82 and 0.84, respectively). Using CAP, AUROC curves for detection of S≥2 and S≥3 were good (0.76, 0.77, respectively). We also proposed cut-off value of CAP to detect S≥2 and S≥3 to be 263 and 319db/m, respectively, and fragmented CK-18 level to detect S≥2 and S≥3 (194 and 294 U/L, respectively). Conclusions. Both the fragmented CK-18 level and the CAP, but not NAFLD Fibrosis Score, were well correlated with hepatic steatosis grade as assessed by US.
机译：背景。这项研究的目的是评估非酒精性脂肪性肝病（NAFLD）患者血清碎裂的细胞角蛋白18（CK-18），可控制的衰减参数（CAP）和通过超声（US）评估的肝脂肪变性之间的关系。方法。招募接受腹部US检查的患者，然后使用Fibroscan？测量CAP。酶联免疫吸附法检测血清CK-18片段。 US评估的肝脂肪变性程度分为轻度（S1），中度（S2）和重度（S3）。结果。本研究共纳入109名患者。 CAP和CK-18片段水平与肝脂肪变性等级显着相关，rs分别为0.56和0.68，p = 0.001。 NAFLD纤维化评分与肝脂肪变性等级相关性很弱（= -0.096，p = 0.318）。使用零散的CK-18水平，S≥2和S≥3的接收器工作特性（AUROC）曲线下面积非常好（分别为0.82和0.84）。使用CAP，AUROC曲线检测S≥2和S≥3的效果很好（分别为0.76、0.77）。我们还建议将CAP的截止值检测到S≥2和S≥3分别为263和319db / m，并提出CK-18碎片水平以检测S≥2和S≥3（194和294 U / L ， 分别）。结论。根据美国的评估，CK-18的片段化水平和CAP均与肝脂肪变性等级密切相关，而CKFL和CAP则与NAFLD纤维化得分均不相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号