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首页> 外文期刊>International Journal of Inflammation >Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication
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Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication

机译：间歇性lau行患者的循环抗β2-糖蛋白I抗体与内皮功能障碍，炎症和亚硝酸盐血浆水平高相关

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Our aim is to investigate a possible association of circulating anti-beta2-glycoprotein I antibodies (ABGPI) with the endothelial dysfunction, nitric oxide bioactivity dysregulation, and the inflammatory status that surrounds peripheral arterial disease. We carried out an observational translational study, including 50 male patients with intermittent claudication and a healthy control group of 10 male subjects, age and sex matched with the cases. Flow-mediated arterial dilatation (FMAD) was assessed as a surrogate of endothelial dysfunction, and C-reactive protein (hsCRP) was determined as a marker of inflammation. Nitrite plasma levels were measured by colorimetric analysis. Circulating ABGPI titer was detected with indirect immunofluorescence. Titers <1 : 10 represented the reference range and the lower detection limit of the test. Circulating ABGPI titer ≥1 : 10 was detected in 21 (42%) patients and in none of the control subjects (P<0.01). Patients with ABGPI titer ≥1 : 10 had a lower FMAD (P=0.01). The CRP levels were higher in patients with ABGPI titer ≥1 : 10 (P=0.04). The nitrite plasma levels were higher in patients with ABGPI titer ≥1 : 10 (P<0.01). These data suggest that these circulating ABGPI may collaborate in the development of atherosclerosis; however, further prospective studies are required to establish a causal relationship.
机译：我们的目的是研究循环抗β2-糖蛋白I抗体（ABGPI）与内皮功能障碍，一氧化氮生物活性失调以及周围动脉疾病的炎症状态之间的可能联系。我们进行了一项观察性转化研究，包括50名间歇性lau行的男性患者和10名男性受试者的健康对照组，年龄和性别与病例相匹配。血流介导的动脉扩张（FMAD）被评估为内皮功能障碍的替代物，C反应蛋白（hsCRP）被确定为炎症的标志物。亚硝酸盐血浆水平通过比色分析测量。间接免疫荧光检测循环ABGPI滴度。滴度<1：10表示参考范围和检测的下限。在21名（42％）患者中和在任何对照受试者中均未检测到循环ABGPI滴度≥1：10。 ABGPI滴度≥1：10的患者的FMAD较低（P = 0.01）。 ABGPI滴度≥1：10的患者的CRP水平较高（P = 0.04）。 ABGPI滴度≥1：10的患者的亚硝酸盐血浆水平更高（P <0.01）。这些数据表明这些循环的ABGPI可能在动脉粥样硬化的发展中协同作用。但是，需要进一步的前瞻性研究来建立因果关系。

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